Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1991-06-18
1994-02-01
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303873, 5303917, 424 8591, A61K 3900, C07K 1300
Patent
active
052833232
ABSTRACT:
The present invention discloses a process for enhancing antibody response to an antigen. A novel step in the process is the preparation of a conjugate of the antigen with an anti-immunoglobulin. The conjugate thus prepared is then administered to a host for in vivo effect or presented to T and B cells in a suitable culture system for in vitro response. The present invention by increasing immunogenicity makes it possible to produce antibodies against very low doses of antigens and otherwise weak or insufficient antigens or synthetic vaccines.
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Berzofsky Jay A.
Kawamura Hajime
Carlson K. Cochrane
Hill Jr. Robert J.
The United States of America as represented by the Department of
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