Method of producing IGF-1

Details Method of producing IGF-1 Method of producing IGF-1

1993-07-02

1995-10-17

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 694, 4353201, 530303, 530399, 530402, 530412, 530416, 530417, 530422, 530427, 530414, 436161, C12P 2104, A61K 3828, C07K 1400, C12N 1517

Patent

active

054590523

ABSTRACT:
Ala-Glu-IGF-I is a novel compound which exerts IGF-I activity and is a precursor for the preparation of IGF-I. Ala-Glu-IGF-I may by converted to IGF-I by renaturation after recombinant production in E. coli under specified conditions and then cleaving Ala-Glu from the IGF-I.

REFERENCES:
patent: 4933434 (1990-06-01), Rudolph et al.
patent: 4961969 (1990-10-01), Hershenson et al.
patent: 4965344 (1990-10-01), Hermann
patent: 5158875 (1992-10-01), Miller et al.
Winkler et al., Bio/Technology, vol. 3, pp. 990-1000 (1985).
Wong et al., Gene, vol. 68, pp. 193-203 (1988).
Forsberg et al., J. Biochem., vol. 271, pp. 357-363 (1990).
Meng et al., J. of Chromatography, vol. 443, pp. 183-192 (1988).
Saito et al., J. Biochem., vol. 101, No. 1, pp. 123-134 (1987).
Light et al., Biochemistry, vol. 26, pp. 5556-5564 (1987).
Rudolph et al., Z. Physiol Chem., vol. 364, No. 7, pp. 813-820 (1983).
States et al., Nature, vol. 286 pp. 630-632 (1980).
Hager et al., Analytical Biochem., vol. 109, pp. 76-86 (1980).
Marston et al., Bio/Technology, vol. 2, pp. 800-804 (1984).
Forsberg et al. 1990 Biochem J. 271:357-363.
Marston 1986, The Purif. of Euk. poleypep. syn. in E. coli. Biochem. J. 240:1-12.
Sambrook et al 1988, Molecular Cloning: A Laboratory Manual, Cold Spr. Harbor Lab. Press, CSH, N.Y.
Peters, Gene, vol. 35, pp. 83-89 (1985).
Bornstein, P., et al., "Regulatory Elements in the First Intron Contribute to Transcriptional Control of the Human .alpha.1(I) Collagen Gene", Proc. Natl. Acad. Sci. USA 84:8869-8873 (Dec. 1987).
Weiss, M. J., et al., "Structure of the Human Liver/Bone/Kidney Alkaline Phosphatase Gene", J. Biol. Chem. 263(24):12002-12010 (Aug. 25, 1988).
Kieran, M., et al., "The DNA Binding Subunit of NF-.kappa.B Is Identical to Factor KBF1 and Homologous to the rel Oncogene Product", Cell 62:1007-1018 (Sep. 7, 1990).

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