Method of producing human pluripotent hematopoietic colony stimu

Details Method of producing human pluripotent hematopoietic colony stimu Method of producing human pluripotent hematopoietic colony stimu

1997-03-12

1998-09-15

Kemmerer, Elizabeth C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530416, 530417, 530418, 530420, 435695, C07K 114, C07K 118, C07K 122, C07K 130

Patent

active

058080082

ABSTRACT:
Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5.times.10.sup.8 U/mg protein.

REFERENCES:
patent: 4621050 (1986-11-01), Sugimoto et al.
patent: 4810643 (1989-03-01), Souza
patent: 5043156 (1991-08-01), Matsumoto et al.
patent: 5532341 (1996-07-01), Welte et al.
patent: 5662895 (1997-09-01), Welte et al.
patent: 5670146 (1997-09-01), Welte et al.
Platzer, E., et al., Biological Characterization of Human Pluripotent Colony-stimulating factor (abstract).
Welte, K., et al., Purification and Biochemical Characterization Human Pluripotent Hematopoietic Colony-stimulating Factor produced by Human Bladder Carcinoma Cell Line (abstract).
Metcalf, Hemopoietic Colonies, ed. Metcalf, Springer-Verlag, New York, pp. 9, 4, 200 (1977).
Nicola, N.A., et al., Blood 54 (3):614-627 (1979).
Lusis et al., Blood 57: 13-21 (1981).
Abdoud et al., Blood 58 (6): 1150-1154 (1981).
Morstyn, G., et al., J. Cell. Physiol. 109: 133-142 (1981).
Wu, M.-C., et al., J. Clin. Invest. 67: 1588-1591 (1981).
Moore, M.A.S., J. Cell. Physiol. Supplement, vol. 1: 53-64 (1982).
Okabe et al., J. Cell. Physiol. 110: 43-47 (1982).
Metcalf et al., J. Cell. Physiol. 116: 198-206 (1983).
Nicola, N.A., et al., J. Biol. Chem. 258 (14): 9017-9023 (Jul. 25, 1983).
Vadas, M.A., et al., J. Immunol. 130 (2): 795-799 (Feb. 1983).
Clark Lewis, J. Biol. Chem. 259: 7488-7492 (1984).
Dexler, Nature 309: 746-747 (1984).
Gasson, J.C., et al., Science 226: 1339-1342 (1984).
Nathan, C.F., et al., J. Exp. Med. 160: 600-605 (1984).
Tsuneoka et al., Cell Structure and Function 9: 67-81 (1984).
Gabrilove et al., Blood 66: 407-415 (Aug. 1985).
Moore, M.A.S., et al., in Mediators in Cell Growth and Differentiation, vol. 37 pp. 147-158 (1985).
Nicola, N.A., et al., Nature 314: 625-628 (Apr. 18, 1985).
Nicola, N.A., et al., J. Cell. Physiol. 124: 313-321 (1985).
Nicola, N.A., Methods in Enzymology 116: 600-619 (1985).
Platzer, E., et al., Modern Trends in Human Leukemia VI, Springer-Verlag, Neth et al. (Eds) pp. 418-422 (1985).
Platzer, E., et al., J. Exp. Med. 162: 1788-1801 (Dec. 1985).
Welte, K., et al., Modern Trends in Human Leukemia VI, Springer-Verlag, Neth. et al. (Eds.) pp. 398-401 (1985).
Welte, K., et al., Proc. Natl. Acad. Sci., USA 82: 1526-1530 (Mar. 1985).
Nagata, S., et al., Nature 319:415-418 (Jan. 30, 1986).
Nagata, S., et al., The EMBO Journal 5 (3):575-581 (1986).
Nomura, H., et al., The EMBO Journal 5 (5): 871-876 (1986).

Affiliated with

Also associated with

Rating

Method of producing human pluripotent hematopoietic colony stimu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of producing human pluripotent hematopoietic colony stimu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of producing human pluripotent hematopoietic colony stimu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-88862