Method of producing human epidermal growth factor

Details Method of producing human epidermal growth factor Method of producing human epidermal growth factor

1983-06-09

1985-07-09

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424100, 514 2, A61K 3522, A61K 3702

Patent

active

045281866

ABSTRACT:
A method for producing a human epidermal growth factor in high yield and high purity by adding particles of an aluminum or magnesium silicate of the formula z.2 (or 6) SiO.sub.2.xH.sub.2 O where Z is Al.sub.2 O.sub.3 or 2MgO and x is the number of water molecules in each molecule of the compound, to human urine under neutral to acid conditions to adsorb the factor on the particles and then eluting the factor with an alkaline solution.

REFERENCES:
Chem. Abstracts, vol. 84, 1976, 84:27148a, Gregory, et al., Isolation of the Urogastrones . . . .
Chem. Abstracts, vol. 91, 1593m, Hirata, et al., "Epidermal Growth Factor (Urogastrone) in Human Fluids . . . ".

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