Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Reexamination Certificate
2004-12-07
2008-08-05
Dentz, B. (Department: 1625)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
C549S552000
Reexamination Certificate
active
07408008
ABSTRACT:
The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
REFERENCES:
patent: 6150416 (2000-11-01), Kick et al.
Baker, C.T. et al.:: Design, Synthesis, and Conformational Analysis of a Novel Series of HIV Protease Inhibitors; Biorg. & Med. Chem. Letters (1998) 8: 3631-3636.
Berge, S.M. et al.: Pharmaceutical Salts; J. of Pharmaceutical Salts; J. of Pharmaceutical Sciences (1977) 66(1): 1-19.
Chino, M. et al.: Efficient method to prepare hydroxyethylamine-based aspartyl protease inhibitors with diverse P1side chains; Tetrahedron (2002) 58: 6305-6310.
Dörner, B. et al.: The Synthesis of Peptidomimetic Combinatorial Libraries Through Successive Amide Alkylations; Bioorg. & Med. Chem. (1996) 4(5): 709-715.
Gould, P.L.: Salt selection for basic drugs; Intl J. of Pharmaceutics (1986) 33: 201-217.
Kick, E.K. et al.: Expedient Method for the Solid-Phase Synthesis of Aspartic Acid Protease Inhibitors Directed toward the Generation of Libraries; J. Med. Chem. (1995) 38: 1427-1430.
Lebon, F. et al.: Approaches to the Design of Effective HIV-1 Protease Inhibitors; Current Med. Chem. (2000) 7: 455-477.
Tamamura, H. et al.: Synthesis of potent β-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies; Org. Biomol. Chem. (2003) 1: 2468-2473.
Coats Steve J.
Hlasta Dennis J.
Schulz Mark J.
Dentz B.
Gallis David E
Janssen Pharmaceutica N.V.
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