Method of producing genetically modified astrocytes and uses the

Details Method of producing genetically modified astrocytes and uses the Method of producing genetically modified astrocytes and uses the

1997-05-24

2000-08-22

Hauda, Karen M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435 691, 435 701, 435325, 435363, 435368, 435455, C12N 1585, C12N 508, C12N 506, C12N 1563

Patent

active

061068276

ABSTRACT:
A genetically modified astrocyte for gene therapy is provided. The genetically modified astrocyte includes one or more stably introduced DNA sequences selected from DNA encoding a selectable marker, DNA encoding a poison pill, and DNA encoding a molecule useful for gene therapy. The genetically modified astrocyte may be produced utilizing plasmids and non-viral transfection methods, as are also provided by the subject invention. Methods for producing and utilizing the genetically modified astrocytes and regulating the engineered products, as well as kits thereof, are further provided.

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