Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide
Reexamination Certificate
2001-08-22
2008-07-08
Lilling, Herbert J. (Department: 1651)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using a micro-organism to make a protein or polypeptide
C435S071100, C435S071200, C435S106000, C530S317000
Reexamination Certificate
active
07396665
ABSTRACT:
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion
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Higaki Tomoji
Kanda Munekazu
Matsuda Mitsunori
Tsuboi Masaru
Ueda Satoshi
Astellas Pharma Inc.
Lilling Herbert J.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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