Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1995-08-28
1996-07-09
Ziska, Suzanne E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
4351723, 935 6, 935 32, 935 34, 935 36, 536 231, 536 241, C12N 1500, C12P 2106, C07H 2104
Patent
active
055344194
ABSTRACT:
A method of producing foreign gene products which comprises (1) transforming animal cells either (a) by using two plasmids, namely a plasmid containing the MMTV LTR and a foreign gene encoding a physiologically active substance inserted therein downstream from the LTR and a plasmid containing the LTR and a glucocorticoid receptor protein gene inserted therein downstream from the LTR, or (b) by using one plasmid comprising the LTR, a glucocorticoid receptor protein gene located downstream from the LTR, another LTR and a foreign gene encoding a physiologically active substance located downstream from the latter LTR, and (2) cultivating the transformed animal cells in a medium containing glucocorticoid in an amount effective for inducing mRNA transcription.
REFERENCES:
patent: 4374927 (1983-02-01), Sninsky
Lee et al Nature 294: 228, 1981.
Miesfeld et al. Cell 46: 389, 1986.
Hynes et al PNAS 80: 3637, 1983.
Mayers et al PNAS 80: 5866, 1983.
Vanderbret et al Abstract CA 107: 70998h, from Mol. Endo. 1(1): 68-74, 1987.
Ko & Takano, DNA 8, 127 (1989).
Ko et al., Gene 84, 383 (1989).
Ko Minoru S. H.
Takano Toshiya
Daiichi Pharmaceutical Co. Ltd.
Ziska Suzanne E.
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