Method of producing flowable R,S-thioctic acid, R,S-thioctic aci

Details Method of producing flowable R,S-thioctic acid, R,S-thioctic aci Method of producing flowable R,S-thioctic acid, R,S-thioctic aci

1996-03-20

1998-01-06

Lambkin, Deborah

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424464, 549 39, A61K 920, A61K 914, C07D33904

Patent

active

057051925

ABSTRACT:
1. A method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use.
2.1. Known methods of preparing flowable thioctic acid which can be galenically further processed by pressing to highly-concentrated, solid presentations with active-substance contents of more than 200 mg pure substance require the mixing of the thioctic-acid forms of different origins and/or a spraying on of galenic adjuvants from aqueous solution and a subsequent grinding process in order to arrive at a pressable granulate.
2.2. As a result of the fact that thioctic acid of any origin is placed in the fluid bed of a device suited for producing a fluid bed and that a built-up granulate consisting of thioctic acid is obtained by spraying a solution of thioctic acid of any origin onto the matter placed in the fluid bed under simultaneous removal of the solvent, it is possible to make a thioctic-acid form available which does not adhere to the pressing tool or exhibit a tendency to form fissures on the tablet even when tablets with 600 mg or more active-substance content are prepared. The novel R,S-thioctic acid has a specific surface of >0.7 m.sup.2 /g and a number of mesopores with a diameter between 2 and 30 nm.

REFERENCES:
patent: 5376382 (1994-12-01), Goedle et al.
patent: 5455264 (1995-10-01), Beisswenger et al.
patent: 5527539 (1996-06-01), Sarlikiotis et al.

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