Method of producing fine coated pharmaceutical preparation

Details Method of producing fine coated pharmaceutical preparation Method of producing fine coated pharmaceutical preparation

1989-08-18

1991-05-21

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424494, 424499, 424475, 424497, 424493, 427212, 42721335, 42721336, 427 3, 427213, 426384, 426385, A61K 916

Patent

active

050173839

ABSTRACT:
A method of producing a fine coated pharmaceutical preparation, which includes cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as required, a binder to a temperature of not higher than the freezing point of the liquid medium to form frozen particles of the drug and as required the binder, adjusting the particle sizes of the fine frozen particles, mixing the fine frozen particles with a fine powder of a coating material having a particle diameter smaller than the particles at a temperature higher than the freezing point of the liquid medium to cause the fine powder of the coating material to adhere to the surfaces of the particles, and then removing the liquid medium from the resulting coated particles.

REFERENCES:
patent: 3202533 (1965-08-01), Sachsel et al.
patent: 3202731 (1961-04-01), Grevenstuk et al.
patent: 4323478 (1982-04-01), Adams et al.
patent: 4353709 (1982-10-01), Nioh et al.
patent: 4576826 (1986-03-01), Liu et al.
patent: 4753803 (1988-06-01), Klug et al.
patent: 4816264 (1989-03-01), Phillips et al.

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