Method of producing fibrin-specific antibodies using soluble fib

Details Method of producing fibrin-specific antibodies using soluble fib Method of producing fibrin-specific antibodies using soluble fib

1996-06-28

1998-11-17

Saunders, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

4241841, 4351722, 435328, 435346, 53038825, 5303893, 436547, 436548, A61K 3900, C12N 1506, C12N 516, C07N 1636

Patent

active

058375406

ABSTRACT:
The subject invention relates to a method for producing antibodies using as an immunogen a composition comprising soluble crosslinked DesAABB fibrin polymers and soluble non-crosslinked DesAABB fibrin polymers. The invention provides a method for producing fibrin-specific antibodies which, for the purposes of the present invention, are defined as antibodies that specifically bind to soluble crosslinked DesAABB fibrin polymers and soluble non-crosslinked DesAABB fibrin polymers, but which do not specifically bind to: (a) fibrinogen, (b) plasmin-derived fibrinogen degradation products, (c) DesAA fibrin monomers, (d) DesAA fibrin polymers, (e) DesAABB fibrin monomers, (f) crosslinked fibrinogen, (g) DesAA fibrin monomer-fibrinogen complex, and (h) plasmin-derived fibrin degradation products.

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Gussow, F and Seeman, G. Meth. Enzymol. 203: 99-121, 1991.
Rotker, J et al. Eur. J. Biochem.. 155(3): 583-588, Mar. 1986.

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