Compositions – Preservative agents – Anti-corrosion
Patent
1996-12-13
1998-12-01
Lovering, Richard D.
Compositions
Preservative agents
Anti-corrosion
252312, 264 41, 366192, 3661761, 424450, 425 5, 514941, B01J 1300, A61K 9127, B01F 506, B01F 1502
Patent
active
058433341
DESCRIPTION:
BRIEF SUMMARY
This application is filed under 35 USC .sctn.371 from PCT/JP95/01209, filed Jun. 19 1995 based on Japanese patent application 6/137054, filed 20 Jun., 1994.
TECHNICAL FIELD
The present invention relates to a method of producing an emulsion using a high-pressure emulsification equipment. More particularly, the invention relates to a method of producing an emulsion characterized by applying a back pressure equal to not less than 0.2% but less than 5% of the pressure acting on the point of high-pressure emulsifying action in a high-pressure emulsification zone in the course of production of an emulsion with a high-pressure emulsification equipment.
BACKGROUND TECHNOLOGY
In the pharmaceutical field, a great deal of research has been undertaken in recent years into a variety of performance dosage forms known as drug delivery systems (DDS).
One of such DDSs is an emulsion which consists of microglobular particles or droplets. Microglobules not exceeding 100 nm in particle diameter are scarsely taken up in the biological tissues with a well-developed reticuloendothelial system (RES), such as the liver and the spleen, and may selectively permeate into the diseased tissues with enhanced vascular permeability. Therefore, any drug included in such a microglobule may find its way efficiently to the target lesion and emulsions consisting of drug-containing microglobules are of great use as antitumor drugs, antiinflammatory drugs, antiviral drugs, analgesics, antiallergic drugs, antiulcer drugs, and chemotherapeutic drugs, among others (Japanese Kokai Tokkyo Koho (JP Kokai) H2-203 and H3-176425, WO91/07973, WO91/07962, WO91/07964, WO91/10431, etc.). On the other hand, emulsion particles larger than 100 nm in diameter are more readily taken up in tissues with developed RES and, therefore, emulsions consisting of globules with a mean particle diameter of about 200 nm have been used clinically as, for example, infusions for hyperalimentation or nutritional supplementation
An emulsion is generally produced by using a high-pressure emulsification equipment for efficient breaking-up, dispersing, and emulsification.
The conventional high-pressure emulsification equipment is available either in the type which does not involve application of a pressure (back pressure) in a direction reverse to the direction of flow of the emulsion fluid at the outlet of the equipment or the type which involves application of a back pressure equal to about 20-25% of the pressure acting on the point of high-pressure emulsifying action in the high-pressure emulsification zone. Although emulsions can be produced by using such emulsification equipment, a great deal of energy is required for applying a high pressure to the point of emulsifying action in the high-pressure emulsification zone or for causing the emulsion fluid to traverse the point of emulsifying action repeatedly to produce an emulsion consisting of microglobular particles with diameters in the range of tens through hundreds of nanometers. In addition, it is difficult to obtain microglobules uniform in particle diameter. Thus, the conventional high-pressure emulsification equipment is not necessarily a satisfactory equipment. In particular, it is difficult to produce an emulsion consisting of microglobules (a mean particle diameter not greater than 70 nm) by using the conventional high-pressure emulsification equipment.
SUMMARY OF THE INVENTION
The present invention has for its object to provide a method of producing an emulsion consisting of uniform and microfine globules with a reduced energy input (a shorter treatment time or a lower pressure) with ease.
After much research the inventors of the present invention discovered by chance that the above-mentioned object can be accomplished by the simple procedure of applying a back pressure equal to not less than 0.2% but less than 5% of the pressure acting on the point of high-pressure emulsifying action in a high-pressure em ulsification zone (hereinafter referred to as processing pressure) in the course of production of an emul
REFERENCES:
patent: 1817958 (1931-08-01), Zwilgmeyer
patent: 3684251 (1972-08-01), Bowling
patent: 4057223 (1977-11-01), Rosenberger
patent: 4081863 (1978-03-01), Rees
patent: 4344752 (1982-08-01), Gallagher, Jr.
patent: 4383769 (1983-05-01), Pandolfe
patent: 4608211 (1986-08-01), Handjani et al.
patent: 4621023 (1986-11-01), Redziniak et al.
patent: 4664528 (1987-05-01), Rodgers et al.
patent: 5149720 (1992-09-01), DesMarais et al.
patent: 5152923 (1992-10-01), Weder et al.
patent: 5173007 (1992-12-01), Krajieck
patent: 5453447 (1995-09-01), End et al.
patent: 5554382 (1996-09-01), Castor
Abstract of Japanese 55077035.
Derwent Abstract of Japanese 59026128.
Derwent Abstract of Japanese 62001444.
Saheki Akira
Seki Junzo
Lovering Richard D.
Nippon Shinyaku Co. Ltd.
LandOfFree
Method of producing emulsions and an emulsification apparatus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of producing emulsions and an emulsification apparatus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of producing emulsions and an emulsification apparatus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2392919