Method of producing conjugated fatty acids

Details Method of producing conjugated fatty acids Method of producing conjugated fatty acids

1998-10-13

2000-05-09

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435134, 435853, C12N 120, C12P 764

Patent

active

060603046

ABSTRACT:
A method for producing a cis-9, trans-11 fatty acid from a fatty acid containing double bonds in the cis-configuration at positions 9 and 12, includes the step of combining a Lactobacillus microorganism with free fatty acids in a fermentation process. The conjugated fatty acid products can include, for example, cis-9, trans-11 conjugated linoleic acid (CLA).

REFERENCES:
patent: 4603142 (1986-07-01), Burger et al.
patent: 4868001 (1989-09-01), Maruta
patent: 4888326 (1989-12-01), Horrobin
patent: 5017614 (1991-05-01), Pariza et al.
patent: 5070104 (1991-12-01), Pariza et al.
patent: 5162337 (1992-11-01), Elbrecht et al.
patent: 5208356 (1993-05-01), Pariza et al.
patent: 5428072 (1995-06-01), Cook et al.
patent: 5430066 (1995-07-01), Cook et al.
patent: 5504114 (1996-04-01), Cook et al.
patent: 5554646 (1996-09-01), Cook et al.
patent: 5674901 (1997-10-01), Cook et al.
Begin, M.E., et al., "Plasma Fatty Acid Levels in Patients with Acquired Immune Deficiency Syndrome and in Controls," Prostaglandins Leukotrienes and Essential Fatty Acids, 37:135-137 (1989).
Chin, Sou F., et al., "Conjugated Linoleic Acid (9,11-and 10,12-Octadecadienoic Acid) Is Produced in Conventional but Not Germ-Free Rats Fed Linoleic Acid .sup.1,2," Nutrient metabolism, pp. 694-701 (1994).
Chin et al., "Synthesis of CLA by Intestinal Microorganisms," FASEB J. 7, A169 (1993).
Chin et al., "Synthesis of CLA by Intestinal Microorganisms," Food Research Institute, 1992 Annual Report, p. 139-140.
Cook, Mark E., "Exogenous Antigen Challenge and Its Effect on Nutrient Metabolism," Proceedings American Association of Swine Practitioners 25th Annual Meeting (1994).
Cook, et al., "Immune Modulation by Altered Nutrient Metabolism: Nutritional Control of Immune-Induced Growth Depression: Symposium: The Microenvironment of Immune Tissue," Poultry Science, 72:1301-1305 (1993).
Das, U.N., "Can Essential Fatty Acid Deficiency Predispose to AIDS?", Can. Med. Assoc. J., 132:900-902 (Apr. 15, 1995).
Eyssen et al., "Biotransformation of Linoleic Acid and Bile Acids by Eubacterium Lentum," Applied and Environmental Microbiology, 47:39-43 (1984).
Fairbank et al., "Octadeca-911 Dienoic Acid in Diagnosis of Cervical Intraepithelial Neoplasia," Lancet p. 329 (1988).
Fujimoto et al., "Biohydrogenation of Linoleic Acid by Anaerobic Bacteria Isolated from Rumen," Biosci. Biotech, Biochem, 57:1026-1027 (1993).
Ha, Y.L., et al., Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid, Carcinogenesis, 8(12):1881-1887 (1987).
Ha, Y.L., et al., Newly Recognized Anticarcinogenic Fatty Acids: Identification and Quantification in Natural and Processed Cheeses, J. Agric. Food Chem., 37(1):75-81 (1989).
Haumann, B., "Conjugated Linoleic acid offers research promise," Inform. 7:152-159 (1996).
Ip et al., "Mammary Cancer Prevention by Conjugated Dienoic Derivative of Linoleic Acid," Cancer Research, 51,6118-6124 (1991).
Jack et al., "Serum octadeca-9, 11 dienoic acid--an assay of free radical activity or a result of bacterial production?," Clinica Chimica Acta, 224:139-146 (1994).
Kemp et al., "The Hydrogenation of Unsaturated Fatty Acids by Five Bacterial Isolates from the Sheep Rumen, Including a New Species," Journal of General Microbiology, 90:100-114 (1975).
Kepler et al., "Biohydrogenation of Unsaturated Fatty Acids," The Journal of Biological Chemistry, 245:3612-3620 (1970).
Klein, A., et al., "Process of HIV Infection And Changes in The Lipid Membrane Structure of CD4+Cells," AIDS, 6(3):332-333 (1992).
Kohn, A., et al., "Unsaturated Free Fatty Acids Inactivate Animal Enveloped Viruses," Archives of Virology, 66:301-307 (1980).
Kumar, G. Sravan, et al., "Effect of n-6 and n-3 Fatty Acids on the Proliferation of Human Lymphocytes and Their Secretion of TNF-a and IL-2 in Vitro," Nutrition Research, 12:815-823 (1992).
Lee et al., "Conjugated linoleic acid and atherosclerosis in rabbits," Atherosclerosis, 108:19-25 (1994).
The Merck Index, Tenth Edition (1983), p. 790.
Michel, et al., "Interaction of Conjugated Dienoic Derivatives of Linoleic Acid with .beta.-Carotene on Cellular Host Defense," Fed. Am. Soc. Exp. Biol. J., 6:A1102 (1992).
Miller, et al., "Feeding Conjugated Linoleic Acid to Animals Partially Overcomes Catabolic Response Due to Endotoxin Injection," Biochemical and Biophysical Research Communication, 198(3):1107-1112 (1994).
Mills et al., "Hydrogenation of C.sub.18 Unsaturated Fatty Acids by Pure Cultures of A Rumen Micrococcus," Aust. J. Biol. Sci., 23:1109-1113 (1970).
Nicolosi et al., "Dietary Conjugated Linoleic Acid Reduces Aortic Fatty Streak Formation Greater Than Linoleic Acid in Hypercholesterolemic Hamsters," Circulation, 88(suppl):24-58 (1993).
Pariza, M.W., Food Research Institute 1988 Annual Fall Meeting, (Oct. 12, 1988).
Peck, Michael D., et al., "The Esterified Plasma Fatty Acids Profile Is Altered in Early HIV-1 infection," Lipids, 28(7):593-597 (1993).
Thompson et al., "Measurement of The Diene Conjugated Form of Linoleic Acid in Plasma by High Performance Liquid Chromatography: A Questionable Non-Invasive Assay of Free Radical Activity?," Chem. Biol. Interactions, 55:357-366 (1985).
Uchida, K., "Occurrence of Conjugated Dienoic Fatty Acids in The Cellular Lipids of Pediococcus homari," Agr. Biol. Chem., 39(2):561-563 (1975).
Verhulst et al., "Isomerization of Polyunsaturated long Chain Fatty Acids of Propionibacteria," System. Appl. Microbiol., 9:12-15 (1987).
Verhulst et al., "Biohydrogenation of Linoleic Acid by Clostridium sporogenes, Clostridium bifermentans, Clostridium sordellii and Baceriodes sp.," FEMS Microbiology Ecology, 31:255-259 (1985).

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