Method of producing antihypercholesterolemic agents

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S325000, C435S252300, C435S254100, C435S254110, C435S320100, C435S069100, C435S193000, C435S006120, C435S007100, C530S350000, C530S300000

Reexamination Certificate

active

06943017

ABSTRACT:
A method of increasing the production of lovastatin or monacolin J in a lovastatin-producing or non-lovastatin-producing organism is disclosed. In one embodiment, the method comprises the steps of transforming an organism with theA. terreusD4B segment, wherein the segment is translated and where an increase in lovastatin production occurs.

REFERENCES:
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4282155 (1981-08-01), Smith et al.
patent: 4323648 (1982-04-01), Tanzawa et al.
patent: 4342767 (1982-08-01), Albers-Schonberg et al.
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 5030447 (1991-07-01), Joshi et al.
patent: 5151365 (1992-09-01), Dombrowski et al.
patent: 5159104 (1992-10-01), Dabora et al.
patent: 5180589 (1993-01-01), Joshi et al.
patent: 5182298 (1993-01-01), Helms et al.
patent: 5198345 (1993-03-01), Gwynne et al.
patent: 5252474 (1993-10-01), Gewain et al.
patent: 5362638 (1994-11-01), Dahiya
patent: 5744350 (1998-04-01), Vinci et al.
patent: 0 556 699 (1993-08-01), None
patent: WO9512661 (1995-05-01), None
J.T. Kealey, et al., “Production of a Polyketide Natural Product in Nonpolyketide-producing Prokaryotic and Eurkaryotic Hosts,” Proc. Natl. Acad. Sci. USA 95:505-509 1998.
J. Kennedy, et al., “Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis,” Science 284:1368-1372, 1999.
M. Manzoni, et al., “Production and Purification of Statins fromAspergillus terreusStrains,” Botechnol. Tech. 12(7):529-532, 1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of producing antihypercholesterolemic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of producing antihypercholesterolemic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of producing antihypercholesterolemic agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3375702

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.