Method of producing antibodies to a restricted population of T l

Details Method of producing antibodies to a restricted population of T l Method of producing antibodies to a restricted population of T l

1991-09-27

1996-01-02

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 7021, 4351722, 436547, 436548, 53038822, 53038875, G01N 33577

Patent

active

054808952

ABSTRACT:
This invention relates to a method of obtaining antibodies specific to a population of T-lymphocytes (T cells) restricted by V.beta. gene usage. The invention also relates to the antibodies obtained and to methods of using them. According to the invention, T cells are incubated with an effective amount of a superantigen under conditions and for a time sufficient to allow division and growth of T-cells reactive to the superantigen. The incubated T-cells are injected into a mammal, and thereafter serum containing antibodies specific to the incubated and injected T-cells is removed from the mammal.

REFERENCES:
The Journal of Experimental Medicine, vol. 174, No. 4, 1 Oct. 1991, pp. 891-900.

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