Method of producing antibodies

Details Method of producing antibodies Method of producing antibodies

1978-08-11

1980-04-01

Rosen, Sam

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

424 85, 424 86, A01N 102, A61K 3942

Patent

active

041962656

ABSTRACT:
Continuous cell lines of genetically stable fused cell hybrids capable of producing large amounts of monoclonal antibodies against specific viruses and their antigenic determinants have been developed. The cell lines are fused cell hybrids between viral antibody producing cells and myeloma cells. Fused cell hybrids between influenza virus-primed mouse spleen cells and mouse myeloma cells can be maintained indefinitely in culture and continue to produce large amounts of anti-influenza antibody.

REFERENCES:
patent: 2768114 (1956-10-01), Koprowski et al.
Gerhard & Koprowski, Nature, vol. 266, Mar. 4, 1977, pp. 360-361.
Milstein & Herzenberg, Immune System, "Genetics & Regulation," edited by Sercarz et al., (Academic Press), Dec. 1977, pp. 273-275.
Koprowski, Gerhard & Croce, Proc. Nat. Acad. of Sci. (USA), vol. 74, Jul. 1977, pp. 2985-2988.
Milstein & Kohler, "Antibodies in Human Diagnosis & Therapy", edited by Haber & Krause (Raven), Feb. 17, 1977, pp. 271-284.
The Lancet, editorial, Jun. 11, 1977, pp. 1242-1243.
Kohler, Pearson & Milstein, Somatic Cell Genetics, vol. 3, Feb. 7, 1977, pp. 303-312.
Kohler et al., Nature, vol. 256, (Aug. 7, 1975), pp. 495 to 497.
Kohler et al., Eur. J. Immunol., vol. 16, (1976), pp. 511-519.
Galfre et al., Nature, vol. 266, (Apr. 1977), pp. 550-552.
Welsh, Nature, vol. 266, (Apr. 1977), p. 495.

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