Method of producing antibacterial agents and bioconverting micro

Details Method of producing antibacterial agents and bioconverting micro Method of producing antibacterial agents and bioconverting micro

1983-03-03

1985-06-11

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435253, 435886, C12P 1718, C12R 1465

Patent

active

045229198

ABSTRACT:
Improved bioconverting strain of Streptomyces thermotolerans useful in preparing tylosin esters and new antibacterial macrocin or lactenocin ester derivatives of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen.

REFERENCES:
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patent: 4092473 (1978-05-01), Okamoto et al.
patent: 4205163 (1980-05-01), Mori et al.
patent: 4385116 (1983-05-01), Baltz et al.
Sebek et al., Genetics of Industrial Microorganisms, Pub. by American Society for Microbiology, pp. 117-122 (1979).
M. Tsuchiya et al., "Studies on the Effects of 3-Acetyl-4"-Isovaleryltylosin Against Multiple-Drug Resistant Strains of Staphylococcus Aureus", J. Antibiotics 34(3), 305-306 (1981).
M. Tsuchiya et al., "Studies of Tylosin Derivatives Effective Against Macrolide-Resistant Strains: Synthesis and Structure-Activity Relationships", J. Antibiotics 35(6), 661-671 (1982).
Derwent Abstract Nos. 66634C/38, 27592A/15 of Japanese Unexamined Patent Nos. J5 5043-013, J5 3021-182, 3-26-80, 2-27-78 (Sanraku Ocean).
Okamoto et al., "The Activity of 4"-Acylated Tylosin Derivatives Against Macrolide-Resistant Gram-Positive Bacteria: J. Antibiotics 32, 542-544 (1979).
Okamoto et al., "Biological Properties of New Acyl Derivatives of Tylosin", J. Antibiotics 33, 1309-1315 (1980).

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