Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Reexamination Certificate
2007-03-12
2009-08-11
Gonzalez, Porfirio Nazario (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
C556S478000, C568S878000, C568S893000
Reexamination Certificate
active
07572927
ABSTRACT:
A method of producing an o-disubstituted aromatic compound, containing: continuously conducting at least the following steps (a) to (d):(a) a step of mono-lithiating one halogen atom of an o-dihaloaromatic compound, using a first microreactor;(b) a step of making the thus-obtained monolithiated product to react with an electrophilic compound, using a second microreactor, to obtain a monosubstituted-monohaloaromatic compound;(c) a step of lithiating the other halogen atom of the o-dihaloaromatic compound, using a third microreactor; and(d) a step of making the thus-obtained lithiated product successively to react with an electrophilic compound, using a forth microreactor.
REFERENCES:
patent: 2006-241065 (2006-09-01), None
“The 86th Annual Convention (Spring Session) of the Chemical Society of Japan, Preprints”, Cover page, Contents, 3H2-45, and Colophon, published on Mar. 13, 2006.
J. Organometal. Chem., 1980, 193, 283-292.
“The 5th International Workshop on Micro Chemical Plants, Jan. 29-30, 2007, Kyoto Univeristy Katsura Campus, Kyota, Japan”, cover p. 33, and Colophon.
IKCOC-10 Program and Abstracs, Nov. 13-17, 2006, Rihga Royal Hotel Kyoto, Japan, Cover page, p. 218 and Colophon.
J. Am Chem. Soc., Published on Web Feb. 27, 2007.
J. Org. Chem., 1984, 49, 2792-2795.
Henry Gilman et al., “Some Reactions of o-Halobromobenzenes with n-Butyllithium”, J. Amer. Chem. Soc., May 20, 1956, pp. 2217-2222.
Frédéric Leroux et al., “The “Aryne” route to Biaryls Featuring Uncommon Substituent Patterns”, Angew. Chem. Int. Ed., 2002, pp. 4272-4274, vol. 41-No. 22, Wiley-VCH Verlag GmbH & Co., KGaA, Weinheim, Germany.
Laure Boymond et al., “Preparation of Highly Functionalized Grignard Reagents by an Iodine-Magnesium Exchange Reaction and its Application in Solid-Phase Synthesis”, Angew. Chem. Int. Ed, 1998, pp. 1701-1703, vol. 37-No. 12, Wiley-VCH Verlag GmbH, D69451 Weinheim, Germany.
Chemfiles-Enabling Technologies, Microreactor Technology, 2005, pp. 1-20, vol. 5-No. 7, Aldrich Advancing Science, Milwaukee, Wisconsin, USA.
O. Hirotsugu Usutani et al. “Selective Monolithiation of Dihaloarenes using Microreactor”, The 86th Annual Convention (Spring Session) of the Chemical Society of Japan, Cover page, Contents, 3H2-45 to 3H2-48, pp. 374 and 996, vol. 59-No. 3, Mar. 13, 2006, Department of Synethetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan and English-Language translation.
Yutaka Tomida, “Lithiation of Polyhaloarenes using Microreactors”, presented Jun. 24, 2006 in the Inventor's Yoshida's Laboratory, Department of Synethetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan.
Yousuke Ushiogi et al., “Synthesis of Photochromic Diarylethenes using a Microflow System”, The 9th International Conference on Microreaction Technology, Berlin, Germany, Sep. 6-8, 2006, Cover page, Contents of Preprints of the Conference, Dechema, Frankfurt, Germany.
Aiichiro Nagaki et al., “Integrated Micro Flow synthesis Based on Sequential Br-Li Exchange Reactions of p-, m-, and o-Dibromobenzenes”, Chemistry Asian Journal, 2007, pp. 1513-1523, vol. 2, Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany.
Nagaki Aiichiro
Nokami Toshiki
Yoshida Jun-ichi
Buchanan & Ingersoll & Rooney PC
Fujifilm Corporation
Gonzalez Porfirio Nazario
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