Method of producing an antithrombin III-heparin concentrate or a

Details Method of producing an antithrombin III-heparin concentrate or a Method of producing an antithrombin III-heparin concentrate or a

1984-05-18

1985-04-09

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, C07G 700, A61K 3764, A61K 31725, C08B 3710

Patent

active

045100845

ABSTRACT:
In a method of producing an antithrombin III-heparin or an antithrombin III-heparinoid concentrate, heparin or heparinoid is added to human plasma or to antithrombin III containing plasma fractions to form an antithrombin III-heparin or antithrombin III-heparinoid complex, the complex thus formed is adsorbed on an anion exchanger, and eluted with a salt solution; then the antithrombin III-heparin or antithrombin III-heparinoid complex contained in the eluate is separated from salts and undesired proteins, and the resulting product is loyphilized.

REFERENCES:
patent: 3842061 (1974-10-01), Andersson et al.
patent: 3920625 (1975-11-01), Andersson et al.
patent: 4087415 (1978-05-01), Bick et al.
patent: 4388232 (1983-06-01), Eibl et al.
patent: 4446126 (1984-05-01), Jordan
patent: 4465623 (1984-08-01), Chanas et al.
Rosenberg, Chemistry & Physiology of the Human Plasma Proteins, H. Bing, Editor, Pergamon Press (1979), pp. 353-368.
Rosenberg et al., J. of Biol. Chem., vol. 248, No. 18, (1973), pp. 6490-6505.
Thrombosis Research, vol. 5, No. 4 (1974), pp. 439-452 (Miller-Anderson et al.).

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