Method of producing an antibody with a peptide corresponding to

Details Method of producing an antibody with a peptide corresponding to Method of producing an antibody with a peptide corresponding to

1991-11-04

1999-02-02

Fitzgerald, David L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

5303872, 53038873, 530300, 530350, A61K 39395, C07K 1642, C07K 1628

Patent

active

058661298

ABSTRACT:
The invention relates to a method of using a peptide which has the sequence of epitopes which are present on B cell-bound but not secreted IgA. This induces production of the antibody itself. These extracellular peptide segments form, entirely or in part, antigenic epitopes unique to membrane-bound but not secreted IgA.

REFERENCES:
patent: 4636463 (1987-01-01), Altman et al.
Lawton et al., IgA determinants on B-lymphocytes in patients with deficiency of circulating IgA, J. Lab. Clin. Med., 80(1):26-33, Jul. 1972.
Durkin et al., orignin and fate of IgE-bearing lymphocytes. I. Peyer's patches as differentiation site of cell simultaneously bearing IgA and IgE, J. Exp. Med., 154(3):640-648, Sep. 1981.
Emancipator et al. IgA Immune Complex Renal disease 1983. Annals of the N.Y. Academy of Science vol. 409:171-176. Ed. J.R. McGhee and J. Mestecky.

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