Method of producing .alpha.-L-aspartyl-L-phenylalanine methylest

Details Method of producing .alpha.-L-aspartyl-L-phenylalanine methylest Method of producing .alpha.-L-aspartyl-L-phenylalanine methylest

1980-09-19

1982-06-08

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

043338720

ABSTRACT:
A method for preparing an .alpha.-L-aspartyl-L-phenylalanine alkyl ester, which method comprises: reacting a divalent alkali salt of aspartic acid, having an amino-protective group, with an organic halo ester compound, to form a monovalent, alkali-salt, mixed,anhydride aspartate compound; and condensing the mixed,anhydride aspartate compound with an alkyl ester of L-phenylalanine under alkaline conditions and reducing the pH to an acidic condition after condensation to free the amino and carboxyl groups, to form a mixture consisting essentially of the alpha and beta alkyl ester of .alpha.-L-aspartyl-L-phenylalanine.

REFERENCES:
patent: 3786039 (1974-01-01), Ariyoshi et al.
patent: 3830792 (1974-08-01), Tilak
patent: 3879372 (1975-04-01), Boesten
patent: 3901871 (1975-08-01), Anderson
patent: 3933781 (1976-01-01), Bachman et al.

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