Method of producing .alpha.,.beta.-unsaturated ketolactones

Details Method of producing .alpha.,.beta.-unsaturated ketolactones Method of producing .alpha.,.beta.-unsaturated ketolactones

1992-04-01

1993-07-20

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D307935

Patent

active

052295290

ABSTRACT:
The present invention provides a method of preparing .alpha.,.beta.-unsaturated ketolactones which are useful for production of prostaglandins having one or more halogen substituent(s) at the 16 or 17 portion in high yield, in which, a dimethyl (2-oxoalkyl) phosphonate having one or more halogen substituents, a starting material, is reacted with a bicyclolactone aldehyde under the presence of an alkali metal hydride and a zinc compound.

REFERENCES:
patent: 4032576 (1977-06-01), Nelson
patent: 4788299 (1988-11-01), Riefling
patent: 4810805 (1989-03-01), Shibasaki et al.

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