Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-12-09
1976-10-05
Rizzo, Nicholas S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2601125R, 260471R, C07D21524, C07C10119, C07C10352
Patent
active
039844170
ABSTRACT:
Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.
REFERENCES:
patent: 2666058 (1954-01-01), Neher
patent: 3121707 (1964-02-01), Anderson et al.
patent: 3790598 (1974-02-01), Damico et al.
patent: 3793314 (1974-02-01), Nardi et al.
patent: 3795666 (1974-03-01), Kohig et al.
White et al., "Principles of Biochemistry," 1968 pp. 107-110.
Ariyoshi Yasuo
Toi Koji
Yasuda Naohiko
Ajinomoto Co. Inc.
Berman Hans
Rizzo Nicholas S.
Wheeler David E.
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