Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1997-02-28
1999-10-19
Marx, Irene
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352404, 43524046, 43524048, 435244, 549510, 549511, C12P 1702
Patent
active
059687894
ABSTRACT:
This invention relates to a method of producing a taxane-type diterpene(s) wherein tissues or cells of a plant which produces taxane-type diterpene(s) is cultured in the presence of at least one selected from the group consisting of jasmonic acids, compounds containing a heavy metal, complex ions containing a heavy metal, heavy metal ions, amines and antiethylene agents, a method of producing a taxane-type diterpene wherein the tissues or the cells of the plant are cultured by controlling the oxygen concentration in a gas phase in a culture vessel to less than the oxygen concentration in the atmosphere from the initial stage of the culture, or by controlling the dissolved oxygen concentration in a fluid medium which is in contact with the tissue or the cell to less than the saturated dissolved oxygen concentration at that temperature from the initial stage of the culture, a method of producing a taxane-type diterpene wherein the tissue or the cell of the plant is cultured in a culture vessel, while oxygenic gas containing 0.03-10% of carbon dioxide is used as aeration gas to be introduced to the vessel, and a method of obtaining highly productive cultured cells for the taxane-type diterpene wherein cultured cells of the plant which produces the taxane-type diterpene are separated into a plurality of layers according to the difference in their specific gravities, and the cells contained in at least one layer are cultured, then highly productive cultured cells for the taxane-type diterpene are selected from among those cultured cells.
The present invention allows industrial production of a taxane-type diterpene such as taxol which is useful as a therapeutic agent for cancer.
REFERENCES:
patent: 5015744 (1991-05-01), Holton
patent: 5019504 (1991-05-01), Christen et al.
patent: 5407816 (1995-04-01), Bringi et al.
E.R.M. Wickremesine et al., 1992 World Congress On Cell and Tissue Culture, Development of callus and cell suspension . . . , vol. 28, No. 3, Mar. 1992.
Hara Yasuhiro
Higashi Yosuke
Matsubara Kouichi
Ohnishi Naoto
Suga Chuzo
Marx Irene
Mitsui Chemicals, Ltd.
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