Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2006-04-18
2006-04-18
Leith, Patricia (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Reexamination Certificate
active
07029707
ABSTRACT:
A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones is also disclosed.
REFERENCES:
patent: 4154823 (1979-05-01), Schutt
patent: 4248861 (1981-02-01), Schutt
patent: 5178735 (1993-01-01), Manabe et al.
patent: 5234947 (1993-08-01), Cherksey
patent: 5273754 (1993-12-01), Mann
patent: 5296224 (1994-03-01), Schwabe
patent: 5380826 (1995-01-01), Castor et al.
patent: 5401502 (1995-03-01), Wunderlich et al.
patent: 5440055 (1995-08-01), Castor
patent: 5466455 (1995-11-01), Huffstutler, Jr. et al.
patent: 5512285 (1996-04-01), Wilde
patent: 5554382 (1996-09-01), Castor
patent: 5578307 (1996-11-01), Wunderlich et al.
patent: 5585386 (1996-12-01), Rosenbaum
patent: 5639441 (1997-06-01), Sievers et al.
patent: 5698199 (1997-12-01), Mori et al.
patent: 5733577 (1998-03-01), Myers et al.
patent: 5750709 (1998-05-01), Castor
patent: 5770207 (1998-06-01), Bewicke
patent: 5776486 (1998-07-01), Castor et al.
patent: 5776935 (1998-07-01), Danysz et al.
patent: 5821450 (1998-10-01), Fedida
patent: 5854064 (1998-12-01), Castor et al.
patent: 5877005 (1999-03-01), Castor et al.
patent: 5891465 (1999-04-01), Keller et al.
patent: 5906825 (1999-05-01), Seabrook, Jr. et al.
patent: 5906848 (1999-05-01), Kreuter et al.
patent: 5976550 (1999-11-01), Engel et al.
patent: 5977120 (1999-11-01), Giles, Jr.
patent: 6024998 (2000-02-01), Kreuter et al.
patent: 6025363 (2000-02-01), Giles, Jr.
patent: 6045825 (2000-04-01), Cody
patent: 6068846 (2000-05-01), Cho et al.
patent: 6080410 (2000-06-01), Bewicke
patent: 6095134 (2000-08-01), Sievers et al.
patent: 6117431 (2000-09-01), Ramazanov et al.
patent: 6140375 (2000-10-01), Nagahama et al.
patent: 6143300 (2000-11-01), Stevenot
patent: 6159473 (2000-12-01), Watkins et al.
patent: 6174542 (2001-01-01), Hinton et al.
patent: 6207164 (2001-03-01), Kreuter et al.
patent: 6238696 (2001-05-01), Wang
patent: 6238722 (2001-05-01), Meadows
patent: 6241988 (2001-06-01), Erdelmeier et al.
patent: 6277396 (2001-08-01), Dente
patent: 6280736 (2001-08-01), Erdelmeier et al.
patent: 6288109 (2001-09-01), Chatterjee et al.
patent: 6290985 (2001-09-01), Ream et al.
patent: 6312736 (2001-11-01), Kelly et al.
patent: 2002/0192241 (2002-12-01), Chen et al.
patent: 987026 (2000-03-01), None
patent: 943121 (1963-11-01), None
patent: WO 99/61038 (1999-12-01), None
patent: WO 00/72861 (2000-07-01), None
Ashraf-Khorassani et al. Supercritical Fluid Extraction of Kava Lactones from Kava Root and Their Separation Via Supercritical Fluid Chromatography; Chromatographia (1999), 50(5/6) pp. 287-292.
Lopez-Avila et al. Supercritical Fluid Extraction of Kava Lactones from Piper Methysticum (Kava) Herb; Journal of High Resolution Chromatography (1997), 20(10), pp. 555-559.
Avila et al., Supercritical Fluid Extraction of Kava Lactones from Piper Methysticum (Kava) Herb, Midwest Research Institute, vol. 20, Oct. 1997.
Khorassani et al., Supercritical Fluid Extraction of Kava Lactones from Kava Root and Their Separation Via Supercritical Fluid Chromatography, Chromatographia, vol. 50, Sep. 1999.
Uy Nguyen et al., Extraction and Fractionation of Spices Using Supercritical Fluid Carbon Dioxide, Presented at the 5thInternational Symposium on Supercritical Fluids, 1998.
Int'l Search Report dated May 2, 2003 for PCT/US02/31771.
Cappaso, A. et al., Experimental Investigations of the Synergistic-Sedative Effect of Passiflora and Kava, Acta Therapeutica 21, 1995, pp. 127-140, vol. 21, No. 2.
Kubatova, Alena et al., Comparison of Subcritical Water and Organic Solvents for Extracting Kava Lactones from Kava Root, Journal of Chromatography, Jul. 20, 2001, pp. 187-194, vol. 923., No. 1-2, Elsevier Science Publishers B.V. Amsterdam, NL.
Rex, Andre et al., Anxiolytic-Like Effects of Kava—Kava in the Elevated Plus Maze Test-A Comparison with Diazepam, Progress in Neuro-Psychopharmacology & Biological Psychiatry, Jun., 2002, pp. 855-860, vol. 26, No. 5.
Williamson, E.M., Synergy and Other Interactions in Phytomedicines, Phytomedicine, Sep. 2001, pp. 401-409, vol. 8, No. 5.
Birdsall William
Gow Robert
Pierce Brian
Pierce John
HerbalScience LLC
Leith Patricia
Troutman Sanders LLP
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