Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2006-12-05
2006-12-05
Sullivan, Daniel M. (Department: 1636)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S018000, C800S021000, C800S022000
Reexamination Certificate
active
07145055
ABSTRACT:
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
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Ando Kiyoshi
Habu Sonoko
Ito Mamoru
Kobayashi Kimio
Koyanagi Yoshio
Central Institute for Experimental Animals
Dreger Ginger R.
Heller Ehrman LLP
Sullivan Daniel M.
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