Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-04-20
1995-04-25
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530417, 530830, 530831, 435236, C07K 320, C07K 1506
Patent
active
054100224
ABSTRACT:
The invention relates to a method of producing virus-safe highly purified factor VIII. The method includes a combination of the following measures:
REFERENCES:
patent: 3920625 (1975-11-01), Anderson et al.
patent: 4160025 (1979-07-01), Eibl et al.
patent: 4297344 (1981-10-01), Schwinn et al.
patent: 4379085 (1983-04-01), Williams
patent: 4404187 (1983-09-01), Schwinn et al.
patent: 4405603 (1983-09-01), Schwinn et al.
patent: 4640834 (1987-02-01), Eibl et al.
patent: 4673733 (1987-06-01), Chandra et al.
patent: 4814435 (1989-03-01), Schwarz et al.
patent: 4904641 (1990-02-01), Eibl et al.
patent: 4909251 (1990-03-01), Seelich
patent: 5043428 (1991-08-01), Heimburger et al.
patent: 5118794 (1992-04-01), Grangeorge et al.
patent: 5143838 (1992-09-01), Kraus et al.
patent: 5186945 (1993-02-01), Shanbrom
patent: 5252709 (1993-10-01), Burnouf et al.
Burnouf-Radosevich, M. et al., "Chromatographic Preparation of a Therapeutic Highly . . . ", Vox Sang, vol. 62, pp. 1-11, 1992.
Burnouf, T. et al., "A Highly Purified Factor VIII: C concentrate . . . ", Vox Sang, vol. 60, pp. 8-15, 1991.
Prince, A. M., et al. "The development of virus-free Labile . . . ", Eur. J. Epidemiol., vol. 3 (2), pp. 103-118, 1987.
Schwinn, H. et al., "Progress in purification of virus-inactivated Factor VIII . . . ", Arzeneimi Helforschung, 39(10), pp. 1302-1305, 1989 Medline AN 90121338.
Mannucci, P. M. et al., "Outbreak of Hepatitis A Among Italian Patients with Haemophilia", The Lancet, vol. 339: p. 819 (Mar. 28, 1992).
Mannucci, P. M. et al., "Low Risk of Viral Infection After Administration of Vapor-Heated Factor VIII Concentrate", Transfusion, vol. 32: pp. 134-138 (1992).
Muller, W., "New Ion Exchangers for the Chromatography of Biopolymers", Journal of Chromatography, 510, pp. 133-140 (1990).
Directive EC III/8115/89-EN, Commission of the European Community.
Brummelhuis, H. G. J., "Preparation of the Prothrombin Complex", Methods of Plasma Protein Fractionation, pp. 117-125 (1980).
Pape, W. J. W. et al., "Standardization of an in vitro Red Blood Cell Test for Evaluating the Acute Cytotoxic Potential of Tensides", Arzneim.-Forsch./Drug Res. 40., pp. 498-502 (1990).
Vogelaar, E. F., "Contributions to the Optimal Use of Human Blood", Vox Sanguinis, vol. 26, pp. 118-127 (1974).
Hartert, H., "Thombosis and Bleeding Disorders", Academic Press, New York pp. 70-76 (1971).
Seelich, T., "Fibrinogen, Fibrin and Fibrin Glue, Side Effects of Therapy with Clotting Factor Concentrates", F. K. Schattauer Verlag, Stuttgart, New York pp. 199-208 (1980).
Suomela, H., "Preparation and Properties of a Therapeutic Factor IX Concentrate", Vox Sanguinis, Journal of Blood Transfusion, Immunohaemotology and Immunopathology, vol. 33, pp. 37-50 (1977).
Rubinstein, D. B., M.D., "Inability of Solvent-Detergent (S-D) Treated Factor VIII Concentrate to Inactivate Parvoviruses . . . ", American Journal of Hematology 35:142 (1990).
Chemical Abstracts, vol. 111, No. 22, 201439j, Nov. 27, 1989.
Chemical Abstracts, vol. 114, No. 5, 39082a, Feb. 4, 1991.
Rozenberg, XII International Congress on Blood Transfusion Abstracts, Moscow, pp. 473-475 (Aug. 17-23, 1969).
Chemical Abstracts, Pharmaceuticals, vol. 84, No. 16, 111640n, Apr. 19, 1976.
Eibl Johann
Elsinger Friedrich
Gritsch Herbert
Linnau Yendra
Schwarz Otto
Immuno Aktiengesellschaft
Sayala C.
Wityshyn Michael G.
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