Method of producing a bone substitute material

Details Method of producing a bone substitute material Method of producing a bone substitute material

1985-06-04

1986-11-18

Lusignan, Michael R.

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

128 92YQ, 623 16, 623 18, 623 66, A01N 102, A61F 100, A61F 124, A61F 504

Patent

active

046235531

ABSTRACT:
For producing the bone substitute material from collagen and hydroxyapatite, an aqueous solution of cleaned collagen is mixed with a cross-linking agent causing only a partial cross-linking, and the mixture is lyophilized.
The quantity of the cross-linking agent is chosen such that the collagen retains its resorbability and its absorptivity vis-a-vis bodily fluids, the material further showing no undesirable side effects.
Preferably less than 1% by weight of formaldehyde, one of the preferred cross-linking agents, is added, with reference to the dry weight of collagen, and sintered apatite grains with a diameter of 50-300 .mu.m are used.
Such a bone substitute material is stronger and less tearable as previously known materials and insures a good promotion of the growth of own bone tissue and the substitution by it.

REFERENCES:
patent: 4516276 (1985-05-01), Mittelmeier et al.

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