Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1998-06-26
2000-08-15
Sisson, Bradley
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530324, 530399, A61K 3801, A61K 3824, A61K 3800
Patent
active
061038822
ABSTRACT:
The method of the present invention is suitable for the commercial high-level production of a protein or peptide which can be used as a prophylactic and therapeutic drug for various diseases such as senile dementia, cerebrovascular dementia (dementia arising from cerebrovascular disorders), dementia associated with genealogical retroplastic diseases (e.g. Alzheimer's disease, Parkinson's disease, Pick's disease, Huntington's disease, etc.), dementia associated with infectious diseases (e.g. Creutzfeldt-Jakob's and other virus diseases), dementia associated with endocrine or metabolic disease or toxicosis (e.g. hypothyroidism, vitamin B12 deficiency, alcoholism, intoxication by drugs, metals, and organic compounds), dementia associated with tumorigenic diseases (e.g. brain tumor), dementia associated with traumatic diseases (e.g. chronic subarachnoidal hemorrhage), and other types of dementia, depression, hyperactive child syndrome (microencephalopathy), and disturbance of consciousness. Additionally, the ligand polypeptide of the present invention has prolactin secretion-stimulating and inhibiting activities.
REFERENCES:
Nishimura et al. Synthesis of new peptides with prolactin-releasing activity by a combination of recombinant DNA technology and a cysteine-specific cyanylation reaction. Chem. Pharm. Bull. 46(9):1490-1492, Sep. 1998.
Copy of communication dated Nov. 27, 1998 with European Search Report re European Pat. Appln. No. 98111725.2-2106.
N. Koyama, et al. "A Novel Procedure For The Preparation of Biologically Active Recombinant Peptides Using a Cyanylation Reaction", Journal of Biotechnology 32 (1994), pp. 272-281.
Nobuyuki Koyama, et al. "A Novel Procedure for the Preparation of Biologically Active Recombinant Peptides Using a Cyanylation Reaction", Journal of Biotechnology, vol. 32, No. 2, 1994, pp. 273-281.
Shuji Hinuma, et al. "A Prolactin-Releasing Peptide in the Brain", Nature, vol. 393, May 21, 1998, pp. 272-276.
Masato Suenaga
Osamu Nishimura
Takeo Moriya
Yoko Tanaka
Buchanan Robert L.
Conlin David G.
Sisson Bradley
Srivastava Devesh
Takeda Chemical Industries Ltd.
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