Method of producing 5-fluorouracil derivatives

Details Method of producing 5-fluorouracil derivatives Method of producing 5-fluorouracil derivatives

1976-11-24

1981-02-03

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40504, C07D40514

Patent

active

042490065

ABSTRACT:
A new and industrially useful method of producing 1(or 1,3-bis)-(tetrahydro-2-furyl)-5-fluorouracil or a mixture thereof by reacting 5-fluorouracil with 2,3-dihydrofuran at elevated temperature in a closed vessel. Depending upon reaction conditions, each of the above 5-fluorouracil derivatives or a mixture of them is produced.
1,3-Bis-(tetrahydro-2-furyl)-5-fluorouracil thus formed can be converted to 1-(tetrahydro-2-furyl)-5-fluorouracil by solvolysis under non-acidic conditions.

REFERENCES:
patent: 4107162 (1978-08-01), Suzuki et al.
Brossmer et al., Chemical Abstracts, vol. 78 (1973) 58343r.
Brossmer et al., Leibigs Ann. Chem. 762, 160-166 (1972).
Chemical Abstracts, 83:193366 (1975).

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