Method of producing 4-hydroxy-2-pyrrolidinone and method of puri

Details Method of producing 4-hydroxy-2-pyrrolidinone and method of puri Method of producing 4-hydroxy-2-pyrrolidinone and method of puri

1997-11-25

2000-11-28

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548554, 548579, C07D20712, C07D207267, C07D20706

Patent

active

061537667

ABSTRACT:
4-Hydroxy-2-pyrrolidinone which is useful as a raw material of drugs can be produced rapidly and highly selectively in a high yield from an optically active or recemic 4-amino-3-hydroxybutylic acid derivative or a 4-azido-3-hydroxybutyric acid derivative by adding a base catalyst to the reaction system. 4-Hydroxy-2-pyrrolidinone having a high optical purity can be obtained by carrying out recrystallization of optically active 4-hydroxy-2-pyrrolidinone without using a poor solvent.

REFERENCES:
patent: 4003911 (1977-01-01), Scribner et al.
Larcheveque et al., Tetrahedron, 46:4277-4282 (1990).
Pellegata et al., Synthesis, 614-616 (Aug. 1978).
Kobayaski et al., "Preparation of optically active 2-pyrrolidinones as intermediates for antibacterial carbapenems", Chemical Abstracts, 125:151, Aug. 26, 1996.

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