Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1988-09-07
1990-05-29
Lone, Werren B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
568846, 568861, 568862, C07C 2914, C07C 29132
Patent
active
049297732
ABSTRACT:
A method is provided for the production of 1-(4'-isobutylphenyl)ethanol (IBPE) comprising hydrogenating 4-isobutylacetophenone (IBAP) in the absence of a solvent using as a catalyst a treated activated sponge nickel catalyst, e.g., Raney nickel, obtained by subjecting such a catalyst wetted with a protective liquid composed preponderantly of water to a washing treatment with an organic washing liquid in which the aqueous protective liquid is substantially soluble and which is substantially soluble in IBAP or IBPE, e.g., a lower alkanol such as methanol, ethanol or isopropanol. The catalyst optionally may also be washed with IBAP or IBPE after the wash with the organic washing liquid and before being used in the hydrogenation reaction. The washing treatment results in substantially higher conversions IBAP and increased yields of IBPE with a practical reaction time.
REFERENCES:
patent: 4273933 (1981-06-01), Harada et al.
D. P. Curran, J. Am. Chem. Soc. 1983, 105, 5826-5833.
M. Delepine et al., Bull. Soc. Chim. France, 1937, 31-49.
M. Freifelder et al., J. Pharm. Sci. 53, 967 (1964).
M. Freifelder, Catalytic Hydrogenation in Organic Synthesis-Procedures and Commentary, John Wiley, New York (1978), pp. 81-89.
L. Kotlyarevskii et al., Khim. Prom., 1981 (7), 391-393 Translated in Soviet Chemical Industry, 13:7, 813-819 (1981).
D. Nightingale et al., J. Org. Chem. 14, 1089-1093 (1949).
G. G. Hawley, Condensed Chemical Dictionary, 10th Ed., Van Nostrand Reinhold, New York (1959), p. 883.
M. Windholz, Ed., The Merck Index, 10th Ed., Merck & Co., Rahway, NJ (1983), p. 8019.
Cassady D. R.
Hoechst Celanese Corporation
Lone Werren B.
LandOfFree
Method of producing 1-(4'-isobutylphenyl)ethanol does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of producing 1-(4'-isobutylphenyl)ethanol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of producing 1-(4'-isobutylphenyl)ethanol will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-522296