Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1993-06-28
1995-11-21
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241341, 4241391, 4241501, 4241691, 4241701, 4241521, 530300, 530327, 5303871, 5303879, 5303881, 5303882, 5303884, A61K 39395, A61K 3940, C07K 1528, C12P 2108
Patent
active
054684846
ABSTRACT:
The invention described includes methods and compositions useful in preventing infection by Pseudomonas aeruginosa and related organisms. Diclosed is a peptide having the sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseudomonas aeruginosa pilin protein. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against Pseudomonas aeruginosa as well as against such cross-reactive microorganisms.
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Pavlovskis et al, Medical Microbiology 1:97-128, 1982.
Coburn, Curr Top Microbiolog & Immunology 175; 133-141, 1992.
Holder, Serodiagnosis & Immuno Therapy 2: 7-16 1988.
Nicas et al, The Journal of Infetious Diseases 152:716-721, 1985. The role of Exoenzymes.
Lingwood et al, Biochemical & Biophysical Res & Comm 175: 1076-1081, 1991 (Mar.) Glycolipid Receptor Binding Specificity of Exoenzyme S from Pseudomonas Aeruginosa.
Woods et al. Evr. J. Clin. Microbiol 4:163-169, 1985.
Infections With Pseudomonas Aeruginosa.
Ramphal et al, Infection and Immunity 58:600-603 1987.
Baker et al., Infection and Immunity 58:2361-2366 1990, Glycosphingulipid Receptors for Peudomonas Aeruginosu.
Hodges Robert S.
Irvin Randall T.
Paranchych William
Sokol Pamela A.
Woods Donald E.
Dehlinger Peter J.
S.P.I. Synthetic Peptides Incorporated
Sidberry Hazel F.
Stratford Carol A.
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