Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1985-12-04
1989-09-26
Rosen, Sam
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
424101, 4352402, 43524025, A01N 102, C12N 500
Patent
active
048700029
ABSTRACT:
A process for preventing oxidative injury in which living cells are contacted with a protective amount of 3-amino-tyrosine or a derivative thereof. Also provided is a process for preserving a cell sample involving collecting a sample of cells and adding 3-aminotyrosine or a derivative thereof to that cell sample. A process for preventing thermal damage to living cells is also provided which comprises contacting the cells with a thermal protectant amount of 3-aminotyrosine or a derivative thereof, as is a process for protecting living cells from damage caused by ionizing radiation, which comprises contacting the cells with a radioprotectant amount of 3-aminotyrosine or a derivative thereof. Also provided is a process for suppressing anti-inflammatory reactions in animals which comprises administering an anti-inflammatory amount of 3-aminotrosine or a derivative thereof to an animal.
REFERENCES:
Chemical Abstracts Chemical Substance Index 11th Collective vol.-96-105 (1982-1986) p. 58964 CS.
Huang et al, Chem. Abst. vol. 67 (1967), p. 9082u.
Hagino et al, Chem. Abst. vol. 79 (1973) p. 135256q.
Rout-Chem. Abst. -vol. 63 (1965), p. 2164f.
Huang-J. Pharmacol. Exptl. Therap. vol. 134, (1961) pp. 257-265.
Lefkowitz, Doris L. et al, "Activation of Macrophages with Oxidative Enzymes," Methods in Enzymology, vol. 132, 1986, pp. 537-548.
Kiel, Johnathan L. et al, "Physiologic Aging of Mature Porcine Erythrocyutes: Effects of Various Metabolites, Antimetabolites, and Physical Stressors," Am. J. Vet. Res., vol. 47, No. 10, Oct. 1986, pp. 2155-2160.
Kiel, Johnathan L. et al, "3-Amino-L-tyrosine and Its Derivatives as Anti-Inflammatory and Immunosuppressive Compounds," Medicine & Biology, 1987, p. 190.
Pruett, S. B. et al, "Relationship Between Oxidative Metabolism and Thiol Production in Macrophage-Like Cell Lines", Federation of American Societies for Experimental Biology, 72nd Annual Meeting, Las Vegas, Nevada, May 1-5, 1988, p. 3611.
Collier Stanton
Rosen Sam
Singer Donald J.
The United States of America as represented by the Secretary of
LandOfFree
Method of prevention of oxidative injury to cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of prevention of oxidative injury to cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of prevention of oxidative injury to cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-187256