Method of preventing skin irritation caused by fecal enzymes

Details Method of preventing skin irritation caused by fecal enzymes Method of preventing skin irritation caused by fecal enzymes

1996-04-12

1999-02-09

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

424 69, A61K 740

Patent

active

058690336

ABSTRACT:
Skin irritation, such as diaper rash, appearing when the skin is allowed to remain in contact with proteolytic enzymes found in feces is prevented by inactivating the fecal proteolytic enzymes by contact with organophilic clays. The organophilic clays are applied to the skin in areas likely to come into contact with feces or to garments such as diapers. A composition suitable for practicing the method of the invention comprises an amount of an organophilic clay effective to inactivate irritating fecal proteolytic enzymes dispersed in a pharmaceutically acceptable non-toxic dermatological vehicle. A fabric incorporating organophilic clay, preferably dispersed in a matrix of a superabsorbent polymer is useful for preparing diapers for infants that can help to prevent skin irritation by fecal enzymes.

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