Method of preventing restenosis following coronary angioplasty

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 8, 514822, 530350, 530395, 530855, 530856, A61K 3816, A61K 3817, C07K 14435, C07K 1446

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active

055232922

ABSTRACT:
The present invention comprises a method of alleviating restenosis, post-PTCA or other coronary arterial intervention, and more particularly, to the use of ancrod to prevent restenosis in the coronary arteries.

REFERENCES:
Canadian Journal of Surgery, vol. 33, No. 3, 1990, Toronto, pp. 207-210 Cole, C. W. et al "Heparin-Associated Thrombocytopenia and Thrombosis:Optimal Therapy with Ancrod", p. 208, col. 3, results.
Journal of Nuclear Medicine, vol. 33, No. 5, May 1992, New York, pp. 845-856 Schwartz R. S. et al. "Fibrin Deposition Following Coronary Artery Injury" Quantitation by I-125 Fibrinogen in a Porcine Restenosis Model.
"The Restenosis Paradigm Revisited: An Alternative Proposal for Cellular Mechanisms", Robert S. Schwartz et al, JACC vol. 20, No. 5, Nov. 1, 1992:1284-93.
"Use of Defibrinating Agents Ancrod and Reptilase in the Treatment of Thromboembolism"; H Kwann; pp. 239-251, 1973.
"Therapeutic Defibrination in the Treatment of Thrombotic Disease"; W. R. Bell; pp. 490-493, 1968.
"Blood Fibrinolytic Activity during Arvin Therapy"; W. R. Pitney et al; pp. 165-171, 1969.
"Prolonged Coagulation Defect (Defibrination Syndrome) in Malayan Viper Bite"; pp. 621-626; 1963.
"The Isolation and Properties of the Thrombin-like Activity from Ancistrodon Rhodostoma Venom"; M. P. Esnauf et al; pp. 582-590, 1967.
"Direct Effect of Fibrinogen-clotting Enzymes on Plasminogen Activator Secretion from Human Endothelial Cells"; T. Soszka et al; Thrombosis and Haemostasis 54: 164, 1985.
"Effects of Ancrod: Normalization of Fibrinolytic Enzyme Abornmalities in Patients with SLE and Lupus Nephritis":; P. Glas-Greenwalt et al; J Lab Clin Med 105: No. 1, 99-107, 1985.
"Lupus Nephritis with Thrombosis and Abnormal Fibrinolysis: Effect of Ancrod Therapy"; K. S. Kant et al; J Lab Clin Med 105: No. 1, 77-88, 1985.
"The Effect of Arvin on Blood Coagulating Factors"; W. Bell et al; Brit J. Haemat. 15, pp. 589-602, 1968.
"The Action of Arvin on Fibrin Stabilizing Factor (factor XIII)"; G. H. Barlow et al; Res Comm Chem Path Pharm 1: 39-42, 1970.
"Arvin in Peripheral Arterial Circulatory Disorders. Controlled Multicenter Trials"; G. K. Wolf; Europ. J. Clin Pharmacol 9: 387-392, 1976.
"Controlled Defibrination in the Treatment of Peripheral Vascular Disease"; J. A. Dormandy et a;; Angiology 29: 80-88, 1978.
"The Effects of Ancrod, the Coagulating Enzyme from the Venom of Malayan Pit Viper (A. rhodostoma) on Prothrombin and Fibrinogen Metabolism and Fibrinopeptide A Release in Man"; W. R. Bell; J Lab Clin Med 91: 592-604, 1978.
"In Vivo Effects of Agkistrodon Rhodostoma Venom. Studies with Fibrinogen"; E. Regoeczi et al; I. J. Clin Invest 45: 1202-1212, 1966.
"Defibrinogenating Enzymes"; W. R. Bell; Chapter 45 from Colman R, et al (Eds). Hemostasis and Thrombosis. J. B. Lippincott. Phila; pp. 886-900, 1987.
"Isotopic Studies of Therapeutic Coagulation with a Coagulating Enzyme"; W. Bell; J. Clin Invest 49: 1872-1879, 1970.
"Possible Pathway for Formation of Fibrin Degradation Products During Ancrod Therapy"; C. McKillop et al; Nature (London) 255: 638-639, 1975.
"Anticoagulant Therapy with a Purified Fraction of Malayan Pit Viper Venom"; A. A. Sharp et al; Lancet 1: 493-99, 1968.
"Deficiency of a Plasma Factor Stimulating Vascular Prostacyclin Generation in Patients with Lupus Nephritis and Glomerular Thrombi and its Correction by Ancrod": In-vivo and in-vitro Observations; K. S. Kant et al; Thromb Res 27: 651-58, 1982.
"The Laboratory Investigation of Fibrinolysis". In: Coagulation and Hemostais; G. Lower et al; Thompson J (ed). Churchill-Livingston., Edinburgh 222-260, 1980.
"The Place of Thrombolytic and Defibrinating Agents in the Treatment of Venous Thromboembolism": In: Thromboembolism: Advances in Etiology, Prevetnion, and Management.; H. Kwaan et al; Advances in Etiology, Prevetnion, and Management. Nicholaides A (Ed.). MTP Medical Publ. Lancaster, England, 251-267, 1975.
"Fibrinolysis in Vivo Predicts a Favorable Outcome in Patients with Glomerular Thrombi During Treatment with Ancrod"; S. Kant et al; The Seoul Journal of Medicine, vol. 29, No. 2: 155-165, Jun. 1988.
"Production of the Generalized Shwartzman Reaction in Rabbits by Ancrod (`Arvin`) Infusion and Endotoxin Injection"; C. Krishnamurti et al; Brit. J. Maemat 25: 111-122, 1973.
"Precipitation of Ancrod-Induced Soluble Fibrin by Aprotinin and Norepinephrine"; Muller-Berghaus et a;; Thrombosis Research 2: 305-322, 1973.
"The Effect of Intraperitoneal Malayan Pit Viper Venom on Adhesion and Peritoneal Healing"; E. C. Ashby et al; Brit U. Surg. 57: 863, 1970.
"Acquired Resistance to Treatment with Arvin"; W. Pitney et al; Lancet 1: 79-81, 1969.
"In Vivo Behavior of the Coagulant Enzyme from Agkistrodon Rhodostroma Venom: Studies Using I-Arvin"; E. Regoeczi et al; Br J. Maemat 16: 573, 1969.
"Effect of a Fibrinolytic Agent (Arvin) on Wound Healing and Collagen Formation"; P. J. L. Holt et al, Heberden Society, p. 335. No date given.
"Effects of Arvin in Mice"; Simone Silberman et al; Experimental and Molecular Pathology 14, 67-74, 1971.
"Pharmacology and Toxicology of a Defibrinating Substance from Malayan Pit Viper Venom"; A. Ashford et al; Pharmacology Department, Twyford Laboratories Limited, London N.W. 10. The Lancet pp. 486-489 1968.
"Experimental Arterial Thromboembolism in Baboons"; Laurence A. Harker et al; The American Society for Clinical Investigation, Inc.; vol. 64, Aug. 1979, pp. 559-569.
"Stimulation of Fibrinogen Synthesis by Thrombin in Rabbits with Ancrod-Induced Afibrinogenenmia"; Barbara M. Alving et al; Amer. J. Physiol. Now, vol. 233: 562-567, 1977.
"Effects of Ancrod (Arvin) in Mice: Studies of Plasma Fibrinogen and Fibrinolytic Activity", Simone Silberman et al; British Journal of Haematology, 1973, 24, 101.
"Fibrinogen-Independent Release of Plasminogen Activator in Ancrod-Treated Rabbits"; C. Krishnamurti et al; Thrombosis and Haemostasis 54: 170 (abstract), 1985.
"The Effect of Arvin Upon Cardiac Function"; M. Klein et al; Proceedings of the Society for Experimental Biology and Medicine, vol. 132: 1123-1126, 1969.
"Comparison of Ancrod and Heparin as Anticoagulants Following Endarterectomy in the Dog"; T. M. Daniel et al; Ann. Surg. August: 223-228, 1976.
"Arvin Treatment for Sickle-Cell Crisis"; The Lancet, pp. 542-543, Sep. 7, 1968.
"Streptokinase in Acute Myocardial Infarction"; The New England Journal of Medicine, vol. 301, No. 15, Oct. 11, 1979, pp. 797-802.
"Plasminogen Activator Inhibitor: A Physiologic Regulator of Fibrinolysis"; C. Krishmaurti; AFCR Hematology, Clinical Research, vol. 34, No. 2, 1986.
"Ancrod Enhances the Thrombolytic Effect of Urokinase and Recombinant Tissue-Type Plasminogen Activator"; Abstracts, JACC, vol. 9, No. 2, Feb. 1987.
"Controlled Trail of Ancrod and Heparin in Treatment of Deep-Vein Thrombosis of Lower Limb"; Davies et al; The Lancet, Jan. 15, 1972, pp. 113-115.
"Subcutaneous Ancrod in Prevention of Deep Vein Thrombosis After Hip Replacement Surgery"; Belch et al; Thrombosis Research 25; 23-31, 1982.
"Treatment of Central Retinal Vein Thrombosis with Ancrod"; Bowell et al; The Lancet, Jan. 24, 1970, pp. 173-174.
"Central Retinal Vein Thrombosis", Gent et al; Thrombosis Research 14; 61-66. 1979.
"Low-Dosage Ancrod for Prevention of Thrombotic Complications after Surgery for Fractured Neck of Femur", Barrie et al; British Medical Journal, Oct. 19, 1974, pp. 130-133.
"Subcutaneous Ancrod after Operation for Fractured Hip--a Dose-Ranging and Feasibility Study"; Lowe et al; Thhrombos. Haemostas., 1978.40, pp. 134-143.
"Controlled Trial of Ancrod in Ischemic Stroke"; Hossmann et al; Arch Neurol--vol. 40, Dec. 1983, pp. 803-808.
"Defibrinogenation with Arvin in Thrombotic Disorders"; W. R. Bell. 1974.
"Clinical Effects of Bites by Malayn Viper"; Reid et al; The Lancet, Mar. 23, 1963, pp. 617-621.
"The Proteolytic Action of Arvin on Human Fibrinogen"; Ewart et al; Biochem. J. (1970) 118, 603-609.
"Characterization of Peptides Released from Human Fibrinogen by Arvin"; Biochim. Biophys. Acta, 200 (1970) 587-589.
"The Mechanism of Action of Arvin and Reptilase"; Kwaan et al; pp. 36

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