Method of preventing preeclampsia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C514S172000, C514S026000, C514S025000, C536S004100

Reexamination Certificate

active

08048868

ABSTRACT:
A method of preventing preeclampsia including administering to a patient during an early stage of pregnancy a prophylactically-effective amount of resibufogenin. The administration of resibufogenin is periodically repeated. The method serves to prevent hypertension, proteinuria, and intrauterine growth restriction.

REFERENCES:
patent: 2004/0171087 (2004-09-01), Rech-Weichselbraun et al.
patent: 2006/0134106 (2006-06-01), Adair
patent: 2007/0014722 (2007-01-01), Puschett
patent: 2007/0292968 (2007-12-01), Anslyn et al.
Libby et al, “Pre-eclampsia and the later development of type 2 diabetes in mothers and their children: an intergenerational study”, Diabetologia (2007) 50:523-530.
Conrad, “Animal models of pre-eclampsia: do they exist?”, Fetal Medicine Review 1990; 2: 67-68.
Roberts et al., “Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy”, Hypertension 2003; 41; 437-445, American Heart Association.
Pridjian et al., “Preeclampsia. Part 2: Experimental and Genetic Considerations”, Obstetrical and Gynecological Survey, vol. 57, No. 9, pp. 619-640.
Ianosi-Irimie et al, “A Rat Model of Preeclampsia”, Clinical and Experimental Hypertension, 8:605-617, 2005.
Puschett, “The role of excessive volume expansion in the pathogenesis of preeclampsia”, Medical Hypotheses (2006) 67, 1125-1132.
Vu et al., “Involvement of Marinobufagenin in a Rat Model of Human Preeclampsia”, Am J. Nephrol 2005;25:520-528.
Schoner, “Endogenous cardiac glycosides, a new class of steroid hormones”, Eur. J. Biochem. 269, 2440-2448 (2002), FEBS 2002.
Fedorova et al., “Endogenous Na,K Pump Ligands Are Differentially Regulated During Acute NaCI Loading of Dahl Rats”, Circulation. Dec. 12, 2000, pp. 3009-3014.
Uddin et al., “Marinobufagenin Inhibits Proliferation and Migration of Cytotrophoblast and CHO Cells”, Placenta 29 (2008) 266-273.
Lamarca et al., “Marinobufagenin Impairs First Trimester Cytotrophoblast Differentiation”, Placenta 27 (2006) 984-988.
Melamed et al., “Molecular and Kinetic Basis for the Mixed Agonist/Antagonist Activity of Estriol”, Molecular Endocrinology 11: 1868-1878, 1997.
Spitz, “Progesterone receptor antagonists”, Current Opinion in Investigational Drugs 2006 7 (10):882-890.
Dvela, “Diverse biological responses to different cardiotonic steroids”, Pathophysiology 14 (2007 159-166.
Schoner et al., “Endogenous and Exogenous Cardiac Glycosides and their Mechanisms of Action”, Am J Cardiovasc Drugs 2007 7 (3) pp. 173-187.
Feldmann et al., “Role of Endosomal Na+—K+-ATPase and cardiac steroids in the regulation of endocytosis”, Am J Physical Cell Physiol 293: C885-C896, 2007.

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