Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1988-12-20
1993-11-16
Kight, III, John
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424 40, 424 54, 424 86, 514631, 514636, 514885, 514957, 514958, A61L 904
Patent
active
052621570
ABSTRACT:
Pneumocystis carinii pneumonia may be prevented in a subject susceptible to infection by Pneumocystis carinii by administering to the subject an amount of a pentamidine in aerosol form effective to prevent infection by Pneumocystis carinii and thus prevent Pneumocystis carinii pneumonia. Also, this invention provides a composition for the prevention of Pneumocystis carinii pneumonia which comprises an amount of a pentamidine effective to prevent infection by Pneumocystis carinii and thus prevent Pneumocystis carinii pneumonia in aerosol form and a pharmaceutically acceptable carrier.
REFERENCES:
patent: 4119096 (1978-10-01), Drews
patent: 4649911 (1987-03-01), Knight et al.
Navin et al., "Intravenous Versus Intramuscular Administration of Pentamidine", [Letter]. N. Engl. J. Med. 1984; 311:1701-2.
Waldman et al., "Pentamidine Isethionate Levels In Lungs, Livers, and Kidneys of Rats After Aerosol or Intramuscular Administration", Amer. Rev. Resp. Dis., 108:1004-6 (1973).
Armstrong Donald
Bernard Edward M.
Acquah Sam A.
Kight III John
Sloan-Kettering Institute for Cancer Research
White John P.
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