Method of preventing or treating pneumonia in immobilized patien

Details Method of preventing or treating pneumonia in immobilized patien Method of preventing or treating pneumonia in immobilized patien

1996-07-23

1998-06-09

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514266, 514269, 514274, 514382, 544243, 544256, 544264, 544267, 544268, 544277, 544315, A61K 3152, A61K 31505

Patent

active

057634475

ABSTRACT:
A method of promoting drainage of mucous secretions in the congested airways of a bedridden/immobilized patient or an intubated/mechanically-ventilated patient is disclosed. The method comprises administering to the airways of the patient a uridine phosphate such as uridine 5'-triphosphate (UTP) or P.sup.1,P.sup.4 -di(uridine-5')tetraphosphate, an analog of UTP, or any other analog, in an amount effective to promote drainage of fluid in the congested airways, including sinuses, by hydrating mucous secretions or by stimulating ciliary beat frequency in the airways. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or eye drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative instillation or suppository form.

REFERENCES:
patent: 5292498 (1994-03-01), Boucher
patent: 5420116 (1995-05-01), Puchelle et al.
p. 520 "Mecial-Surgical Nursing: Assessment and Management of Clinical Problems" by S. Lewis and I. Collier, 2nd ed. 1987, McGraw-Hill, New York.
I. Kappestein, et al. Eur. J. Clin. Microbiol. Infect. Dis. 11(6), 504-8 (1992).
B. deBoisblanc, et al., Chest 103, 1543-7 (1993).
D. Craven, et al. Am. Rev. Respir. Dis. 133, 792-6 (1986).
T. Inglis, J. Hosp. Infect. 30, 409-13 (1995).
P. Mahul, et al. Intensive Care Med. 18, 20-5 (1992).
F. Konrad, et al. Intensive Care Med. 21, 482-89 (1995).
N. Cusack & S. Hourani, Annals N.Y. Acad. Sc. 603, 172-81 (Entitled "Biological Actions of Extracellular ATP"), 1987.
Kenner, et al., J. Chem. Soc. 1954, 2288.
Hall and Khorana, J. Am. Chem. Soc. 76, 5056 (1954).
Merck Index, Monograph No. 9795 (11th Ed. 1989).
R. Goody & F. Eckstein, J. Am. Chem. Soc. 93, 6252 (1971).
E. Rapaport, et al, Proc. Natl, Acad. Sci. USA 78, 838-42 (1981).
K. Ng and L.E. Orgel, Nucleic Acids Res. 15 (8) 3572-80 (1987).
D. Hoard and D. Ott, J. Am. Chem. Soc. 87, 1785-1788 (1965).
M. Yoshikawa, et al., Tetrahedron Lett. 5065-68 (1967).
J. Moffatt and H. Khorana, J. Am. Chem. Soc. 83, 649-59 (1961).
B. Fischer, et al., J. Med. Chem. 36, 3937-46 (1993).
N. Kotchetkov, et al., Tetrahedron Lett. 1993 (1971).
J. Barrio, et al., Biochem. Biophys. Res. Commun. 46, 597 (1972).
J. Secrist, et al., Biochemistry 11, 3499 (1972).
J. Bierndt, et al., Nucleic Acids Res. 5, 789 (1978).
K. Kayasuga-Mikado, et al., Chem. Pharm. Bul. (Tokyo) 28, 932 (1980).
J. Ludwig and F. Eckstein, J. Org. Chem. 54, 631-35 (1989).
G. Blackburn, et al., J. Chem. Soc. Perkin Trans. I, 1119-25 (1984).
T. Myers, et al., J. Am. Chem. Soc. 85, 3292-95 (1963).
F. Eckstein and R. Goody, Biochemistry 15, 1685 (1976).
F. Konrad, et al. Chest 105(1), 237-41 (1994).
F. Konrad, et al. Chest 102(5), 1377-83 (1992).
S. Mason, et al., Br. J. Pharmacol. 103, 1649-56 (1991).
M. Knowles, et al., N. Engl. J. Med. 325, 533-8 (1991).
R. Benali, et al., Am. J. Respir Cell Mol. Biol. 10, 363-8 (1994).
C. Jiang, et al., Science 262, 424-7 (1993).
D. Drutz, et al., abstract entitled "Uridine 5' Triphosphate (UTP) Regulates Mucociliary Clearance Via Purinergic Receptor Activation", presented at Purines '96 conference held in Milan, Italy Jul. 6-9, 1996.
H. Brown, et al., Mol. Pharmacol. 40, 648-55 (1991).
M. Lethem, et al., Am. J. Respir. Cell Mol. Biol. 9, 315-22 (1993).
S. Mason et al., Am. Rev. Respir. Dis. 147, A27 (1993).
C. Vallejo, et al., Biochem. Biophys. Acata, 438, 304-09 (1976).
M. Yoshikawa, et al., Bul. Chem. Soc. (Jpn) 42, 3505-08 (1969).

Affiliated with

Also associated with

Rating

Method of preventing or treating pneumonia in immobilized patien does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preventing or treating pneumonia in immobilized patien, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preventing or treating pneumonia in immobilized patien will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2199402