Method of preventing or limiting reperfusion damage

Details Method of preventing or limiting reperfusion damage Method of preventing or limiting reperfusion damage

1995-04-18

1998-11-24

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544396, 544397, 544400, C07D24104

Patent

active

058408967

ABSTRACT:
There is disclosed a process for preparing ophenyl)pentyl!-1-piperazineacetamide which comprises the steps of (a) cyclizing (-)-(S,S)-N.sup.1,N.sup.2 -bis(1-phenylethyl)-1,2-ethanediamine with 2,3-dibromopropanamide in a reaction-inert solvent in the presence of a base, thus yielding an intermediate; (b) resolving the intermediate of into two stereoisomers and recovering thereby hydrogenolyzing hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce (+) -2-piperazinecarboxamide; (d) reductively N-alkylating (+)-2-piperazinecarboxamide with 5,5-bis(4-fluorophenyl)pentaldehyde under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce a compound of the formula: ##STR1## (e) N-alkylating the compound of Formula (VII) with an alkylating reagent of the formula: ##STR2## wherein W represents a reactive leaving group, in a reaction-inert solvent in the presence of a base to form the nitro analog of the desired compound; and (f) reducing the nitro compound in the presence of a reducing agent in a reaction-inert solvent.

REFERENCES:
patent: 4766125 (1988-08-01), Van Daele
patent: 4880808 (1989-11-01), Van Daele et al.
patent: 4968684 (1990-11-01), Van Daele et al.
patent: 5026853 (1991-06-01), Van Daele et al.
Van Belle et al., CA 111, No. 167017h (1989).
Flameng et al., CA 102, No. 214829 (1985).
Xhonneux et al., CA 105, No. 202980 (1986).
Wood et al., CA 103, No. 189487 (1985).
Liu et al., CA 105, No. 108208 (1986).
Van Belle et al., J. Mol. Cell Cardiol. 21 (Supp. 2) 1989, Abstract 424.
Wainwright et al., Br. J. Pharmacol., 99, Proc. Suppl. 1990 (Abstract).
Ijzerman et al., European Journal of Pharmacology -- Molecular Pharmacology Section, 172 (1989) 273-281.
Van Belle et al, J. Cell. Cardiol. 21, pp. 797-805 (1989).
Stereochemistry of Carbon Compounds by Ernest L. Eliel, pp. 68-74 (1962).

Affiliated with

Also associated with

Rating

Method of preventing or limiting reperfusion damage does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preventing or limiting reperfusion damage, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preventing or limiting reperfusion damage will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1703796