Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing compound doai
Patent
1995-03-22
1998-05-05
Lesmes, George F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing compound doai
436503, 514289, 514294, A61K 3155
Patent
active
057475458
ABSTRACT:
Disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO.sup.- or NO.sup.+ equivalent), or a physiologically concentration effective to cause such neuroprotection.
REFERENCES:
patent: 3328251 (1967-06-01), Smith
patent: 3391142 (1968-07-01), Mills et al.
patent: 4064139 (1977-12-01), Anderson et al.
patent: 4122193 (1978-10-01), Scherm et al.
patent: 4273774 (1981-06-01), Scherm
patent: 4351847 (1982-09-01), Griffith et al.
patent: 4374838 (1983-02-01), Anderson et al.
patent: 4399141 (1983-08-01), Anderson et al.
patent: 4806543 (1989-02-01), Choi
patent: 4888347 (1989-12-01), Woodruff et al.
patent: 5061703 (1991-10-01), Bormann et al.
patent: 5264371 (1993-11-01), Miljanich et al.
patent: 5521215 (1996-05-01), Mechoulam et al.
patent: 5559095 (1996-09-01), Miljanich et al.
Merck Index, Rimantadine, No. 8116, p. 1188.
Merck Idex, Memantine, No. A8, p. APP-2.
Merk Index, Amantadine, No. 373, p. 55.
Turski et al., Nature, 349:414-418.
Kornhuber et al., European Journal of Pharmacology, 166:589-550, 1989.
Borman, European Journal of Pharmacology, 166:591-592, 1989.
Muller, SCRIP 1515, p. 28 (1990).
Tominack and Hayden, Rimantadine and Hydrochloride and Amantadine Hydrochloride, pp. 460-461.
Braunwald et al., Principles of Internal Med. 11th ed. (N.Y. McGraw Hill 1987) pp. 1392-1396 & 2017-2019.
Hahn et al., Proc. Nat'l. Acad. Sci. USA 85:6556-6560 (1988).
Choi et al., Neuron 1:623-634 (1988).
Turski, Arzneim-Forsch./Drug Res. 40(I). Nr. 5 (1990).
Meldrum et al., Trends in Parm. Sciences 11:379-387 (1990).
Rothman et al., Trends in Neurosci. 10:299-302 (1987).
Harrison Robert H.
Lesmes George F.
The Children's Medical Center Corporation
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