Education and demonstration – Visual art or craft – artistic adornment – or color training... – Hair or wig styling
Patent
1996-04-22
1998-12-01
Feisee, Lila
Education and demonstration
Visual art or craft, artistic adornment, or color training...
Hair or wig styling
24423, 24 9463, 24532, 514 2, A61K 3849, A61K 3814, A61F 202, A61F 400
Patent
active
058434364
ABSTRACT:
An agent capable of inhibiting signalling mediated by a .beta..sub.1 integrin cell surface receptor of leukocyte cells will treat a bacterial infection associated with a surface of a foreign body over and around which fibrin has been deposited, or a malignant tumor over and around which tenascin has been deposited. In addition, coating a foreign body with a fibrinolytic agent will prevent chronic bacterial infection associated with the surface of the foreign body. Furthermore, an agent capable of stimulating signalling mediated by a .beta..sub.1 integrin cell surface receptor of leukocyte cells will treat chronic inflammation.
REFERENCES:
Nakamoto et al Investigative Radiology vol. 30: 341-344, (1995) Jun.
Goodman & Gilman Chapter 58 The Pharmacological Basis of Therapeutics p. 2.
Bourdon, M.A., Ruoslahti, E. (1989). Tenascin mediates cell attachment through an RGD-dependent receptor. J. Cell Biology 108:1149-1155.
Chiquet-Ehrismann, R. (1993). Tenascin and other adhesion-modulating
Downey, G.P. (1994). Mechanisms of leukocyte motility and chemotaxis. Current Opinion in Immunol. 6:113-124.
El Khoury, J., Loike, J.,, Cao, L., Thomas, C. and Silverstein, S.C. (1994). Macrophages adhere to glucose-modified basement membrane collagen via their scavenger receptors. J. Biol. Chem. 269:10197-10200.
Friedlander, D.R., Hoffman, S., and Edelman, G.M. (1988). Functional mapping of cytotactin: proteolytic fragments active in cell-substrate adhesion. J. Cell Biol. 107:2329.
Furie M.B., Naperstek, B.L., and Silverstein, S.C. (1987). Migration of neutrophilis across monolayers of cultured mocrovascular endothlial cells. An in vitro model of leucocyte extravasation. J. Cell. Sci. 88:161-175.
Gao, J.X., Wilkins, J., and Issekutz, A.C. (1995). Migration of human polymorphonuclear leukocytes through a synovial fibroblast barrier is mediated by both beta 2 (CD11/CD18) integrins and the beta 1 (CD29) integrins VLA-5 and VLA-6. Cell Immunol. 163:178.
Goodman, S.L., Risse, G., and von der Mark, K. (1989). The E8 subfragment of laminin promotes locomotion of myoblasts over extracellular matrix. J. Cell. Biol. 109:799-809.
Gresham, H.D., Graham, I.L., Anderson, D.C., and Brown, E.J. (1991) Leukocyte adhesion-deficient neutrophils fail to amplify phagocytic function in response to stimulation. Evidence for CD11b/CD18-dependent and -independent mechanisms of phagocytosis. J. Clin. Invest. 88:588.
Joshi, P., Chung, C.Y. Aukil, I., and Erickson, H.P. (1993). Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. J. Cell Sci. 106:389-400.
Klemke, R.L., Yebra, M., Bayna, E.M., and Cherish, D.A. (1994). .alpha..nu..beta.5 directed cell mobility but not adhesion on vitronectin. J. Cell Biol. 127:859-866.
Koukouus, G.K., Gould, V.E., Bhattacharyya, A., Gould, J.E., Howeedy, A.A., and Virtanen, I. (1991). Tenascin in normal, reactive, hyperplastic and neoplastic tissue: biological and pathological implications. Hum. Pathol. 22:636.
Lanir, N., Ciano, P.S., Van De Water, L., Mcdnagh, J., Dvorak, A.N., and Dvorak, H.P. (1988). Macrophage migration in fibrin gel matrices. II. Effects of clotting factor XIII, fibronectin, and glycosaminoglycan content on cell migration. J. Immunol. 140:2340-2349.
Loike, J.D., Cao, L. and Silverstein, S.C. (1995). integrins regulate the chemotaxis of FMLP-Stimulated neutrophils through fibrin gels.
Molecular Biology of the Cell, 6:284a;abstract 1650.
Loike, J.D., El Khoury, J., Cao, L., Richards, C.P., Rascoff, H., Mandevill, J.T.H., Maxfield, F.R., and Silverstein, S.C. (1995).
Fibrin Regulates Neutrophil Migration in Response to Interleukin 8, Leukotriene B4, Tumor Necrosis Factor, and Formyl-Methionyl-121:945-955.
Loike, J.D., Sodeik, B., Cao, L., Leucona, S., Weitz, J.I., Detmers P.A., Wright, S.D., and Silverstein S.C. (1991). CD11c/CD18 on Neutrophils recognizes a domain at the N terminus of the A of fibrinogen. Proc. Natl. Acad. Sci., 88:1044-1048.
Leucyl-Phenylalanin. J. Exp. Med. 1763-1772.
Loike, J.D., Silverstein, R., Cao, L., Solomon, L., Weitz, J.I., Haber, E., Matsueda, G.R., Bernatowicz, M.S., and Silverstein, S.C. (1993). Activated platelets form protected zones of adhesion with fibrinogen and fibronectin-coated surfaces. J. Cell Biol., 121:945-955.
Lundgren-Akerlund, E., Olofsson, A.M., Bergerand, E., and Arfors, K.E. (1993). CD11b/CD18-dependent polymorphonuclear leucocyte interaction with matrix proteins in adhesion and migration. Scan. J. Immunol. 37:569.
Mackie., E.J., Halfter, W., and Liverani, D. (1988). J. Cell Biol. 107:2757-2767.
Mackie, E.J., Chiquet-Ehrismann, R., Pearson, C.A., Inaguma, Y.M., Taya, K., Kawarada, Y., and Sakakura, T. (1987). Proc. Natl. Acad. Sci. 84:4621-4625.
Monboisse, J-C., Garnotel, R., Bellon, G., Ohno, N., Perreau, C, Borel, J.P., and Kefalides. (1994). The .alpha.3 chain of type IV collagen prevents activation of human polymorphonuclear leukocytes. J. Biol. Chem. 269:25475-25482.
Pesheva, P., Probstmeier, R., Skubitz, A.P., McCarthy, J.B., Furcht, L.T. and Schachner, M. (1994). Tenascin-R J1 160/180 inhibits fibronectin-mediated cell adhesion--functional relatedness to tenascin-C. J. Cell Sci. 107:2323-33.
Prieto, A.L., Edelman, G.M., and Crossin, K.L. (1993). Multiple integrins mediate cell attachment to cytotactin/tenascin. Proc. Natl. Acad. Sci. USA 90:10154-8.
Ruegg, C.R., Chiquet-Ehrismann, R., and Alkan, S.S. (1989). Tenascin, and extracellular matrix protein, exerts immunomodulatroy activities. Pro. Natl. Acad. Sci. 86:7637-7441.
Schmidt, A.M., Yan, S.D., Brett, J., Mora, R., Nowygrod, R., and Stern, D. (1993). Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products. J. Clin. Invest. 91:2155.
Sharifi, B.G., D.W. Lafleur, S.M. Schwartz, J.S. Forrester, J.A., Fagin. (1995). Expression of tenascin isoforms are selectively up-regulated following aortic balloon. The FASEB Journal, 9:a611.
Sriramarao, P., Mendler, M., and Bourdon, M.A. (1993). Endothelial cell attachment and spreading on human tenascin is mediated by alpha v beta 3 integrins. J. Cell Sci. 105:1001-12.
Thompson, H.L., and Matsushima, K. (1992). Human polymorphonuclear leucocytes stimulated by TNF-.alpha. show increased adherence to extracellular matrix proteins which is meediated via the CD11b/18 complex. Clin. Exp. Immunol. 90:280-285.
Wehrle-Haller, B. and Chiquet, M. (1993). Dual function of tenascin: simultaneous promotion of neurite growth and inhibition of glial migration. J. Cell Sci. 106:597-610.
Loike John
Silverstein Samuel C.
Bansal Geetha P.
Feisee Lila
The Trustees of Columbia University in the City of New York
White John P.
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