Method of preserving ophthalmic solutions and compositions there

Details Method of preserving ophthalmic solutions and compositions there Method of preserving ophthalmic solutions and compositions there

1995-03-29

1996-11-19

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Peroxide or compositions of or releasing gaseous oxygen or...

514912, A61K 3116

Patent

active

055760287

ABSTRACT:
A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

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Paugh, J., Brennan, N., and Efron, N., "Ocular Response to Hydrogen Peroxide", Amer. J. of Optometry and Physiological Optics, vol. 65, No. 2, pp. 91-98 (1988).
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