Method of preparing vincristine

Details Method of preparing vincristine Method of preparing vincristine

1981-11-16

1983-03-01

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D51904

Patent

active

043754325

ABSTRACT:
VLB, 4'-deoxyleurosidine, leurosine and related 1-methyl vinca dimers are oxidized to vincristine-type compounds in tetrahydrofuran solution employing an aqueous chromate-sulfuric acid solution.

REFERENCES:
patent: 3354163 (1967-11-01), Gorman
patent: 3899493 (1975-08-01), Jovanovics et al.
patent: 4110330 (1978-08-01), Barnett et al.
patent: 4195022 (1980-03-01), Thompson
patent: 4298525 (1981-11-01), Jovanovics et al.
patent: 4310528 (1982-01-01), Jovanovics et al.
Kutney, et al., Heterocycles, vol. 9, No. 2, pp. 201-206 (1978).

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