Method of preparing vincristine

Details Method of preparing vincristine Method of preparing vincristine

1980-04-02

1981-12-01

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D51904

Patent

active

043035841

ABSTRACT:
Vincristine is prepared from VLB sulfate or free base by oxidation with an acidic ferrous perchloratehydrogen peroxide oxidation reagent at about -30.degree. C.

REFERENCES:
patent: 3354163 (1967-11-01), Gorman
Fieser et al., Reagents for Organic Synthesis, John Wiley & Sons, New York, (1967), pp. 472-474.
Groves et al., J. Am. Chem. Soc., 96:16, pp. 5274-5275, 8/7/74.
Groves et al., J. Am. Chem. Soc., 97:24, pp. 7118-7122, 11/26/75.
Groves et al., J. Am. Chem. Soc., 98:3, pp. 859-861, 2/4/76.
Groves et al., J. Am. Chem. Soc., 98:17, pp. 5290-5291, 8/18/76.

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