Method of preparing vicinal aminoalcohols

Details Method of preparing vicinal aminoalcohols Method of preparing vicinal aminoalcohols

1993-02-01

1995-05-02

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549475, 564355, 564356, C07D31500, C07C21500

Patent

active

054121191

ABSTRACT:
The present invention is concerned with the preparation of N-substituted vicinal aminoalcohol derivatives from the corresponding hydroxyl-protected cyanohydrin derivatives by successive partial reduction, transimination using a primary amine, reduction of the resulting imine and optional removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the starting cyanohydrin derivatives.
The present invention is also concerned with certain new enantiomerically pure hydroxyl-protected vicinal aminoalcohols.

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