Method of preparing vascular grafts of human and other umbilical

Details Method of preparing vascular grafts of human and other umbilical Method of preparing vascular grafts of human and other umbilical

1979-06-14

1980-12-16

Clingman, A. Lionel

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Internal tissues

8 9418, 8 9419C, 8 9433, C14C 100

Patent

active

042394929

ABSTRACT:
A method for preparing human and other animal umbilical cords for use as a vascular replacement and/or arterial venous fistula which permits the umbilical cord which is to be grafted to be preformed into a desired predetermined configuration. The method includes roughening the surface of the umbilical cord at the point of juncture with the host tissue, external to the umbilical cord, thereby improving the sealing arrangement at said juncture to allow for puncturing of the graft as well as mechanical retention. Additionally, the method may include the steps of flushing the cord in an aqueous solution either before or after roughening, and then the flushed cord is mounted upon a mandrel having the desired configuration. The roughened and mounted cord may then be immersed in ethyl alcohol until substantially dehydrated, and thereafter fixed in an aldehyde selected from the class consisting of dialdehyde starch and gluteraldehyde, with the aldehyde fixing the roughened tissue into a shape conforming to the mandrel upon which it is mounted.

REFERENCES:
patent: 55740 (1866-06-01), Taylor
patent: 3093439 (1963-06-01), Bothwell
patent: 3523027 (1970-08-01), Hall
patent: 4050893 (1977-09-01), Hancock et al.
B. P. Mindlich et al., Trans. Amer. Soc. Artif. Int. Organs, 1975, 21, pp. 273-278.
B. P. Mindlich et al., Dialysis and Transplant, Aug./Sep. 1976, pp. 19-20.
B. Mindlich, et al., Surgery, 1977, 81, (No. 2), pp. 152-160.
Dardick et al., J. American Medical Association, 1976, 236 (No. 25), pp. 2859-2862.

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