Method of preparing thymosin alpha 1 and derivatives thereof

Details Method of preparing thymosin alpha 1 and derivatives thereof Method of preparing thymosin alpha 1 and derivatives thereof

1982-07-29

1984-08-21

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

044669186

ABSTRACT:
Polypeptides of the sequence Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile--Thr-Lys-Asp-Leu-Lys-Glu-Lys- Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, wherein at least one of the amino acids 10,15,21,25 and/or 28 is present as amide or alkyl amide, and/or amino acid 1 bears an acyl group other than acetyl, having up to 6 carbon atoms, especially an acyl glycine residue. In addition, certain thymosin fragments I to VII are provided and process for producing the substituted thymosin alpha.

REFERENCES:
patent: 4079127 (1978-03-01), Goldstein et al.
patent: 4116951 (1978-09-01), Wang
patent: 4148788 (1979-04-01), Wang
Chem. Pharm. Bull. 28, (1980) 3542-3548.
Angew. Chem. Int. Ed. Engl. 18, (1979) 394,395.

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