Method of preparing thymic factors and composition

Details Method of preparing thymic factors and composition Method of preparing thymic factors and composition

1978-11-27

1980-12-16

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

424 95, 424177, 260112R, A61K 3900, A61K 3512, A61K 3700, C07G 700

Patent

active

042394988

ABSTRACT:
A process for obtaining factors having immunological properties from thymus glands including aseptically collecting thymus glands from freshly slaughtered neo-natal vertebrates, comminuting the glands in an isotonic aqueous solution, removing fat and solids and heating the resulting solution to sterilize it and precipitate proteins. The solution is then rapidly chilled, and possibly frozen, and subsequently subjected to stage-wise fractionation in a water miscible, nonpolar organic solvent having less than 4 carbon atoms to isolate two factors which have immunological properties, one of which is called a suppressor that represses reconstitution of the immune response and the other of which is called a helper that reconstitutes the immune response.

REFERENCES:
patent: 3466367 (1969-09-01), Jaeger et al.
patent: 3657417 (1972-04-01), Brunetti et al.
patent: 4010148 (1977-03-01), Goldstein
patent: 4077949 (1978-03-01), Goldstein
patent: 4082737 (1978-04-01), McGregor et al.
patent: 4128637 (1978-12-01), Naylor et al.
J. of Immunology 117, No. 1, 1976, 313-318.
Khaw, et al., Br. J. Cancer (1973), 28, 288-292.
Miller, et al., Annals New York Academy of Science, pp. 54-60.
Miller, et al., J. of Immunology III, 1973, 1005-1009.
Goldstein, et al., Biochemistry 1966, 1010-1017, vol. 56.
Nathenson, et al., Microbiology 56, 1966, 476-483.
Assaker, et al., "Immunology," 5158.
Theurer-Chem. Abst. vol. 74 (1971), pp. 123, 177y.
Woody et al.,-Chem. Abst., vol. 81 (1974), p. 24043q.

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