Method of preparing substituted phthalides

Details Method of preparing substituted phthalides Method of preparing substituted phthalides

1980-03-24

1982-03-30

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D30788

Patent

active

043223567

ABSTRACT:
Method of preparing chlorthalidone, an antihypertensive agent, and derivatives using a novel 3-(4'-chloro-3'-chlorosulfonylphenyl)phthalide intermediate and derivatives, and method of preparing said novel intermediate, are disclosed.

REFERENCES:
patent: 3055904 (1962-09-01), Graf et al.
patent: 3734966 (1973-05-01), Tahara et al.
patent: 4105690 (1978-08-01), Christidis et al.
Wagner and Zook, Synthetic Organic Chem., John Wiley & Sons, Inc., 1953, pp. 822-823.
Adams Organic Reactions, vol. III, pp. 141, 147 (by Suter).

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